Postpartum Domperidone Use in British Columbia: a Retrospective Cohort Study

Overview

Journal CMAJ Open

Specialty General Medicine

Date 2016 Jun 10

PMID 27280111

Citations 11

Authors

Kate Smolina

Steven G Morgan

Gillian E Hanley

Tim F Oberlander

Barbara Mintzes

Affiliations

Soon will be listed here.

Abstract

Background: Domperidone is commonly used off-label to stimulate milk production in mothers who have low milk supply. The aim of this study was to describe trends, patterns and determinants of postpartum domperidone use.

Methods: This is a retrospective, population-based study involving all women with a live birth between Jan. 1, 2002, and Dec. 31, 2011, in the province of British Columbia. We examined administrative data sets containing person-specific information on filled prescriptions and use of medical services, and we used logistic regression to examine associations between domperidone use and maternal characteristics.

Results: The study population consisted of 225 532 women with 320 351 live births. The prevalence of postpartum domperidone use more than doubled between 2002 and 2011. In 2011, 1 in 3 women with a preterm birth and 1 in 5 women with a full-term birth were prescribed domperidone in the first 6 months postpartum. Women who were older, had a higher body mass index, had a chronic disease, were first-time mothers, delivered more than 1 baby (multiple pregnancy), had a preterm birth or had a cesarian delivery were more likely to fill a postpartum domperidone prescription.

Interpretation: We found an increase in postpartum domperidone use over a 10-year period. More research is needed on maternal and infant health outcomes.

Citing Articles

Longitudinal trends in domperidone dispensing to mothers of very preterm infants and its association with breast milk feeding at infant discharge: a retrospective study.

McBride G, Rumbold A, Keir A, Kunnel A, Buxton M, Jones S BMJ Paediatr Open. 2023; 7(1).

PMID: 37923344 PMC: 10626788. DOI: 10.1136/bmjpo-2023-002195.

Women's experiences with using domperidone as a galactagogue to increase breast milk supply: an australian cross-sectional survey.

McBride G, Stevenson R, Zizzo G, Rumbold A, Amir L, Keir A Int Breastfeed J. 2023; 18(1):11.

PMID: 36750944 PMC: 9903405. DOI: 10.1186/s13006-023-00541-9.

Prevalence of Mental Health Disorders Among Immigrant, Refugee, and Nonimmigrant Children and Youth in British Columbia, Canada.

Gadermann A, Petteni M, Janus M, Puyat J, Guhn M, Georgiades K JAMA Netw Open. 2022; 5(2):e2144934.

PMID: 35166784 PMC: 8848209. DOI: 10.1001/jamanetworkopen.2021.44934.

"Fear of stopping" vs "wanting to get off the medication": exploring women's experiences of using domperidone as a galactagogue - a qualitative study.

Zizzo G, Rumbold A, Grzeskowiak L Int Breastfeed J. 2021; 16(1):92.

PMID: 34886887 PMC: 8656031. DOI: 10.1186/s13006-021-00438-5.

Use and experiences of galactagogues while breastfeeding among Australian women.

McBride G, Stevenson R, Zizzo G, Rumbold A, Amir L, Keir A PLoS One. 2021; 16(7):e0254049.

PMID: 34197558 PMC: 8248610. DOI: 10.1371/journal.pone.0254049.

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