Efficacy of Honeycomb TCP-induced Microenvironment on Bone Tissue Regeneration in Craniofacial Area

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2016 Jun 10

PMID 27279797

Citations 9

Authors

Satoko Watanabe

Kiyofumi Takabatake

Hidetsugu Tsujigiwa

Toshiyuki Watanabe

Eijiro Tokuyama

Satoshi Ito

Hitoshi Nagatsuka

Yoshihiro Kimata

Affiliations

Soon will be listed here.

Abstract

Artificial bone materials that exhibit high biocompatibility have been developed and are being widely used for bone tissue regeneration. However, there are no biomaterials that are minimally invasive and safe. In a previous study, we succeeded in developing honeycomb β-tricalcium phosphate (β-TCP) which has through-and-through holes and is able to mimic the bone microenvironment for bone tissue regeneration. In the present study, we investigated how the difference in hole-diameter of honeycomb β-TCP (hole-diameter: 75, 300, 500, and 1600 μm) influences bone tissue regeneration histologically. Its osteoconductivity was also evaluated by implantation into zygomatic bone defects in rats. The results showed that the maximum bone formation was observed on the β-TCP with hole-diameter 300μm, included bone marrow-like tissue and the pattern of bone tissue formation similar to host bone. Therefore, the results indicated that we could control bone tissue formation by creating a bone microenvironment provided by β-TCP. Also, in zygomatic bone defect model with honeycomb β-TCP, the result showed there was osseous union and the continuity was reproduced between the both edges of resected bone and β-TCP, which indicated the zygomatic bone reproduction fully succeeded. It is thus thought that honeycomb β-TCP may serve as an excellent biomaterial for bone tissue regeneration in the head, neck and face regions, expected in clinical applications.

Citing Articles

Effect of Scaffold Geometrical Structure on Macrophage Polarization during Bone Regeneration Using Honeycomb Tricalcium Phosphate.

Takabatake K, Tsujigiwa H, Nakano K, Chang A, Piao T, Inada Y Materials (Basel). 2024; 17(16).

PMID: 39203286 PMC: 11356497. DOI: 10.3390/ma17164108.

Novel Artificial Scaffold for Bone Marrow Regeneration: Honeycomb Tricalcium Phosphate.

Inada Y, Takabatake K, Tsujigiwa H, Nakano K, Shan Q, Piao T Materials (Basel). 2023; 16(4).

PMID: 36837023 PMC: 9965701. DOI: 10.3390/ma16041393.

[Synthetic bone replacement substances].

Busch A, Jager M Orthopadie (Heidelb). 2022; 51(12):1023-1032.

PMID: 36307604 DOI: 10.1007/s00132-022-04319-5.

Biomimetic Gradient Scaffolds Containing Hyaluronic Acid and Sr/Zn Folates for Osteochondral Tissue Engineering.

Asensio G, Benito-Garzon L, Ramirez-Jimenez R, Guadilla Y, Gonzalez-Rubio J, Abradelo C Polymers (Basel). 2022; 14(1).

PMID: 35012034 PMC: 8747647. DOI: 10.3390/polym14010012.

A Pilot Study of Seamless Regeneration of Bone and Cartilage in Knee Joint Regeneration Using Honeycomb TCP.

Takabatake K, Tsujigiwa H, Yoshida A, Furumatsu T, Kawai H, Oo M Materials (Basel). 2021; 14(23).

PMID: 34885378 PMC: 8658628. DOI: 10.3390/ma14237225.

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