Effect of Folic Acid on Homocysteine and Insulin Resistance of Overweight and Obese Children and Adolescents

Overview

Journal Adv Biomed Res

Specialty Biomedical Engineering

Date 2016 Jun 9

PMID 27274503

Citations 12

Authors

Elham Hashemi Dehkordi

Morteza Sedehi

Zohre Gholipour Shahraki

Reza Najafi

Affiliations

Soon will be listed here.

Abstract

Background: Considering the increasing trend of childhood obesity and subsequent burden of the disease in Iran and other countries and importance of early life intervention for achieving sustained effect on health of children and adolescents, this study aimed to investigate the effect of two different dose of folic acid on homocysteine (Hcy) level and insulin resistance of obese children.

Materials And Methods: In this randomized, double-blind controlled clinical trial study, 60 obese and overweight children aged 5-12 years were enrolled. Selected obese children randomly allocated in two interventional (1 mg/day folic acid and 5 mg/day folic acid, for 8 weeks) and one control groups. Biochemical measurements including folic acid, Hcy, insulin and insulin resistance were measured between and within groups before and after trial.

Results: In each group, 20 obese children were studied. The three groups were age and sex matched. After folic acid administration, mean of Hcy, insulin resistance and insulin decreased significantly in two groups which folic acid administrated with two different doses (P < 0.05). The reduction in studied biochemical variables was similar in two interventional groups (1 and 5 mg folic acid daily) (P > 0.05). Mean differences for Hcy, insulin resistance and insulin, in two intervention groups were significantly higher than the control group (P < 0.0001). Mean differences of Hcy, insulin resistance and insulin, in two intervention groups were not different significantly (P > 0.05).

Conclusion: The findings of current trial showed that folic acid in two studied doses could be a safe and effective supplement for obese children to reduce Hcy level and insulin resistance, which consequently could prevent obesity-related complications including cardiovascular and metabolic disorders.

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References

Cesari M, Zanchetta M, Burlina A, Pedon L, Maiolino G, Sticchi D . Hyperhomocysteinemia is inversely related with left ventricular ejection fraction and predicts cardiovascular mortality in high-risk coronary artery disease hypertensives. Arterioscler Thromb Vasc Biol. 2004; 25(1):115-21. DOI: 10.1161/01.ATV.0000149674.62430.e7. View

de Onis M, Blossner M, Borghi E . Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr. 2010; 92(5):1257-64. DOI: 10.3945/ajcn.2010.29786. View

Daniels S . Complications of obesity in children and adolescents. Int J Obes (Lond). 2009; 33 Suppl 1:S60-5. DOI: 10.1038/ijo.2009.20. View

Garcia G, Trejos J, Restrepo B, Landazuri P . Homocysteine, folate and vitamin B12 in Colombian patients with coronary disease. Arq Bras Cardiol. 2007; 89(2):71-6, 79-85. DOI: 10.1590/s0066-782x2007001400002. View

Papandreou D, Malindretos P, Arvanitidou M, Makedou A, Rousso I . Oral supplementation of folic acid for two months reduces total serum homocysteine levels in hyperhomocysteinemic Greek children. Hippokratia. 2010; 14(2):105-8. PMC: 2895291. View

Song Y, Cook N, Albert C, Van Denburgh M, Manson J . Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial. Diabetes. 2009; 58(8):1921-8. PMC: 2712772. DOI: 10.2337/db09-0087. View

Garanty-Bogacka B, Syrenicz M, Szolomicka-Kurzawa P, Gebala A, Goral J, Krupa B . [Correlation between serum homocysteine levels and selected atherosclerosis risk factors in children and adolescents with simple obesity]. Przegl Lek. 2007; 63(8):645-9. View

Lee Y . Consequences of childhood obesity. Ann Acad Med Singap. 2009; 38(1):75-7. View

Dierkes J, Domrose U, Ambrosch A, Bosselmann H, Neumann K, Luley C . Response of hyperhomocysteinemia to folic acid supplementation in patients with end-stage renal disease. Clin Nephrol. 1999; 51(2):108-15. View

10.

Pena A, Wiltshire E, Gent R, Piotto L, Hirte C, Couper J . Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care. 2007; 30(8):2122-7. DOI: 10.2337/dc06-2505. View

11.

Park S, Georgiades A . Changes in body composition predict homocysteine changes and hyperhomocysteinemia in Korea. J Korean Med Sci. 2013; 28(7):1015-20. PMC: 3708071. DOI: 10.3346/jkms.2013.28.7.1015. View

12.

Gillum R . Distribution of serum total homocysteine and its association with diabetes and cardiovascular risk factors of the insulin resistance syndrome in Mexican American men: the Third National Health and Nutrition Examination Survey. Nutr J. 2003; 2:6. PMC: 194257. DOI: 10.1186/1475-2891-2-6. View

13.

Martos R, Valle M, Morales R, Canete R, Gavilan M, Sanchez-Margalet V . Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children. Metabolism. 2005; 55(1):72-7. DOI: 10.1016/j.metabol.2005.07.008. View

14.

Gallistl S, Sudi K, Mangge H, Erwa W, Borkenstein M . Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents. Diabetes Care. 2000; 23(9):1348-52. DOI: 10.2337/diacare.23.9.1348. View

15.

Solini A, Santini E, Ferrannini E . Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects. Int J Obes (Lond). 2006; 30(8):1197-202. DOI: 10.1038/sj.ijo.0803265. View

16.

Codoner-Franch P, Murria-Estal R, Tortajada-Girbes M, del Castillo-Villaescusa C, Valls-Belles V, Alonso-Iglesias E . New factors of cardiometabolic risk in severely obese children: influence of pubertal status. Nutr Hosp. 2011; 25(5):845-51. View

17.

Tamadon M, Jamshidi L, Soliemani A, Ghorbani R, Malek F, Malek M . Effect of different doses of folic acid on serum homocysteine level in patients on hemodialysis. Iran J Kidney Dis. 2011; 5(2):93-6. View

18.

Freedman D, Mei Z, Srinivasan S, Berenson G, Dietz W . Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study. J Pediatr. 2006; 150(1):12-17.e2. DOI: 10.1016/j.jpeds.2006.08.042. View

19.

Fonseca V, Fink L, Kern P . Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects. Atherosclerosis. 2003; 167(1):105-9. DOI: 10.1016/s0021-9150(02)00386-6. View

20.

Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong W . Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2012; 98(1):151-8. DOI: 10.1016/j.diabres.2012.05.027. View