Cytokine Responses and Epithelial Function in the Intestinal Mucosa

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2016 Jun 9

PMID 27271753

Citations 37

Authors

Joseph C Onyiah

Sean P Colgan

Affiliations

Soon will be listed here.

Abstract

Inflammatory diseases of mucosal organs are significantly influenced by the microenvironment in which they reside. Cytokines found within this microenvironment contribute significantly to endpoint functions of the mucosa. Studies dating back to the 1990s have revealed that epithelial cells are both a source as well as a target for numerous cytokines and that such signaling can substantially influence the outcome of mucosal disease, such as inflammatory bowel disease. Here, we will review literature regarding intestinal epithelial cells as sources and responders to cytokines found in the intestinal milieu. These studies highlight the dynamic nature of these pathways and lend insight into the complexity of treating mucosal inflammation.

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