Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord

Overview

Journal J Neuroendocrinol

Specialty Endocrinology

Date 2016 Jun 5

PMID 27262161

Citations 13

Authors

L Zubeldia-Brenner

C E Roselli

S E Recabarren

M C Gonzalez Deniselle

H E Lara

Affiliations

Soon will be listed here.

Abstract

This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual orientation, reproductive and metabolic programming, and the neuroendocrine mechanism involved in the development of polycystic ovary syndrome phenotype. Moreover, consistent with the wide range of processes in which steroid hormones take part, we discuss the protective effects of progesterone on neurodegenerative disease and the signalling mechanism involved in the genesis of oestrogen-induced pituitary prolactinomas.

Citing Articles

Integrated Assessment for the Estrogenic Effects of Pyrethroid Compounds: Defining the Molecular Initiating Events and Key Events for the Adverse Outcome Pathway.

Ortiz D, Park J, Lee H, Park K Toxics. 2024; 12(3).

PMID: 38535951 PMC: 10975338. DOI: 10.3390/toxics12030218.

The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort.

Plusquin M, Wang C, Cosemans C, Roels H, Vangeneugden M, Lapauw B Environ Health. 2023; 22(1):63.

PMID: 37674219 PMC: 10483875. DOI: 10.1186/s12940-023-01010-w.

Use of Systemic Steroids, Hormone Replacement Therapy, or Oral Contraceptives Is Associated with Decreased Implant Survival in Women.

Zou M, Cohen R, Ursomanno B, Yerke L Dent J (Basel). 2023; 11(7).

PMID: 37504229 PMC: 10377784. DOI: 10.3390/dj11070163.

Ecdysone acts through cortex glia to regulate sleep in .

Li Y, Haynes P, Zhang S, Yue Z, Sehgal A Elife. 2023; 12.

PMID: 36719183 PMC: 9928426. DOI: 10.7554/eLife.81723.

Applying extrusion-based 3D printing technique accelerates fabricating complex biphasic calcium phosphate-based scaffolds for bone tissue regeneration.

Beheshtizadeh N, Azami M, Abbasi H, Farzin A J Adv Res. 2022; 40:69-94.

PMID: 36100335 PMC: 9481949. DOI: 10.1016/j.jare.2021.12.012.

References

Moser J, Bigini P, Schmitt-John T . The wobbler mouse, an ALS animal model. Mol Genet Genomics. 2013; 288(5-6):207-29. PMC: 3664746. DOI: 10.1007/s00438-013-0741-0. View

Deniselle M, Garay L, Gonzalez S, Saravia F, Labombarda F, Guennoun R . Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneurons. Exp Neurol. 2006; 203(2):406-14. DOI: 10.1016/j.expneurol.2006.08.019. View

Kanasaki H, Oride A, Mijiddorj T, Kyo S . Role of thyrotropin-releasing hormone in prolactin-producing cell models. Neuropeptides. 2015; 54:73-7. DOI: 10.1016/j.npep.2015.08.001. View

Lu R, Gao H, Wang H, Cao L, Bai J, Zhang Y . Overexpression of the Notch3 receptor and its ligand Jagged1 in human clinically non-functioning pituitary adenomas. Oncol Lett. 2013; 5(3):845-851. PMC: 3576212. DOI: 10.3892/ol.2013.1113. View

Schaaf C, Shan B, Buchfelder M, Losa M, Kreutzer J, Rachinger W . Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo. Endocr Relat Cancer. 2009; 16(4):1339-50. DOI: 10.1677/ERC-09-0129. View

Lawrence Jr I, Burden H . The origin of the extrinsic adrenergic innervation to the rat ovary. Anat Rec. 1980; 196(1):51-9. DOI: 10.1002/ar.1091960106. View

Linden Hirschberg A . Sex hormones, appetite and eating behaviour in women. Maturitas. 2012; 71(3):248-56. DOI: 10.1016/j.maturitas.2011.12.016. View

Kim J, Lee Y, Ku C, Lee E . The cyclic pentapeptide d-Arg3FC131, a CXCR4 antagonist, induces apoptosis of somatotrope tumor and inhibits tumor growth in nude mice. Endocrinology. 2010; 152(2):536-44. DOI: 10.1210/en.2010-0642. View

Monachelli G, Meyer M, Rodriguez G, Garay L, Sica R, De Nicola A . Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors. Horm Mol Biol Clin Investig. 2015; 6(1):167-73. DOI: 10.1515/HMBCI.2011.006. View

10.

Roselli C, Estill C, Stadelman H, Meaker M, Stormshak F . Separate critical periods exist for testosterone-induced differentiation of the brain and genitals in sheep. Endocrinology. 2011; 152(6):2409-15. PMC: 3206706. DOI: 10.1210/en.2010-1445. View

11.

Wilson C, Davies D . The control of sexual differentiation of the reproductive system and brain. Reproduction. 2007; 133(2):331-59. DOI: 10.1530/REP-06-0078. View

12.

Heaney A, Fernando M, Melmed S . PPAR-gamma receptor ligands: novel therapy for pituitary adenomas. J Clin Invest. 2003; 111(9):1381-8. PMC: 154441. DOI: 10.1172/JCI16575. View

13.

Schumacher M, Mattern C, Ghoumari A, Oudinet J, Liere P, Labombarda F . Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors. Prog Neurobiol. 2013; 113:6-39. DOI: 10.1016/j.pneurobio.2013.09.004. View

14.

Recabarren S, Smith R, Rios R, Maliqueo M, Echiburu B, Codner E . Metabolic profile in sons of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008; 93(5):1820-6. DOI: 10.1210/jc.2007-2256. View

15.

De Nicola A, Labombarda F, Deniselle M, Gonzalez S, Garay L, Meyer M . Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration. Front Neuroendocrinol. 2009; 30(2):173-87. DOI: 10.1016/j.yfrne.2009.03.001. View

16.

Johnson L, Zane R, PETTY C, Neaves W . Quantification of the human Sertoli cell population: its distribution, relation to germ cell numbers, and age-related decline. Biol Reprod. 1984; 31(4):785-95. DOI: 10.1095/biolreprod31.4.785. View

17.

Zanotti S, Canalis E . Notch signaling in skeletal health and disease. Eur J Endocrinol. 2013; 168(6):R95-103. PMC: 4501254. DOI: 10.1530/EJE-13-0115. View

18.

Rosa C, Pohl H, Williams M, Ademoyero A, Chou C, Jones D . Public health implications of environmental exposures. Environ Health Perspect. 1998; 106 Suppl 1:369-78. PMC: 1533270. DOI: 10.1289/ehp.98106s1369. View

19.

Mitsumoto H, Bradley W . Murine motor neuron disease (the wobbler mouse): degeneration and regeneration of the lower motor neuron. Brain. 1982; 105 (Pt 4):811-34. DOI: 10.1093/brain/105.4.811. View

20.

Arnold A, Gorski R . Gonadal steroid induction of structural sex differences in the central nervous system. Annu Rev Neurosci. 1984; 7:413-42. DOI: 10.1146/annurev.ne.07.030184.002213. View