Iminium Catalysis Inside a Self-Assembled Supramolecular Capsule: Modulation of Enantiomeric Excess

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2016 Jun 4

PMID 27259076

Citations 20

Authors

Thomas M Brauer

Qi Zhang

Konrad Tiefenbacher

Affiliations

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Abstract

The noncovalent combination of a supramolecular host with iminium organocatalysis is described. Due to cation-π interactions the reactive iminium species is held inside the host and reacts in this confined environment. The products formed differ up to 92 % ee from the control experiments without added host. A model rationalizing the observed difference is presented.

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