Sex-determining Region Y-box3 (SOX3) Functions As an Oncogene in Promoting Epithelial Ovarian Cancer by Targeting Src Kinase

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 Jun 3

PMID 27251670

Citations 8

Authors

Qin Yan

Fangyuan Wang

Yi Miao

Xiaomei Wu

Mingzhu Bai

Xiaowei Xi

Youji Feng

Affiliations

Soon will be listed here.

Abstract

Ovarian cancer is one of the most common cancers which cause female mortality. The knowledge of ovarian cancer initiation and progression is critical to develop new therapeutic strategies to treat and prevent it. Recently, SOX3 has been reported to play a pivotal role in tumor progression. However, the clinical significance of SOX3 in human ovarian cancer remains elusive, and the identity of SOX3 in ovarian cancer initiation, progression, and the related underlying mechanism is unknown. In this study, we showed that SOX3 expression increased from benign and borderline to malignant ovarian tumors. Subsequently, we found that overexpression of SOX3 in EOC cells promoted proliferation, migration, and invasion, while restrained apoptosis and adhesion of ovarian cancer cells. In contrast, silencing of SOX3 gained the opposite results. Finally, we discovered SOX3 targeted Src kinase in EOC cells. These data imply that SOX3, acting as an oncogene in EOC, is not only a crucial factor in the carcinogenesis but also a promising therapeutic target for EOC.

Citing Articles

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Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in Tumorigenesis.

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Overexpression of Sox3 is associated with promoted tumor progression and poor prognosis in hepatocellular carcinoma.

Feng Y, Xiao F, Yang N, Zhu N, Fu Y, Zhang H Int J Clin Exp Pathol. 2020; 10(7):7873-7881.

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Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish.

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