Animal-adapted Members of the Mycobacterium Tuberculosis Complex Endemic to the Southern African Subregion

Overview

Journal J S Afr Vet Assoc

Specialty Veterinary Medicine

Date 2016 Jun 2

PMID 27246904

Citations 10

Authors

Charlene Clarke

Paul van Helden

Michele Miller

Sven Parsons

Affiliations

Soon will be listed here.

Abstract

Members of the Mycobacterium tuberculosis complex (MTC) cause tuberculosis (TB) in both animals and humans. In this article, three animal-adapted MTC strains that are endemic to the southern African subregion - that is, Mycobacterium suricattae, Mycobacterium mungi, and the dassie bacillus - are reviewed with a focus on clinical and pathological presentations, geographic distribution, genotyping methods, diagnostic tools and evolution. Moreover, factors influencing the transmission and establishment of TB pathogens in novel host populations, including ecological, immunological and genetic factors of both the host and pathogen, are discussed. The risks associated with these infections are currently unknown and further studies will be required for greater understanding of this disease in the context of the southern African ecosystem.

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