Cell Type Specificity of Neurovascular Coupling in Cerebral Cortex

Overview

Journal Elife

Specialty Biology

Date 2016 Jun 1

PMID 27244241

Citations 128

Authors

Hana Uhlirova

Kivilcim Kilic

Peifang Tian

Martin Thunemann

Michele Desjardins

Payam A Saisan

Sava Sakadzic

Torbjorn V Ness

Celine Mateo

Qun Cheng

Kimberly L Weldy

Florence Razoux

Matthieu Vandenberghe

Jonathan A Cremonesi

Christopher Gl Ferri

Krystal Nizar

Vishnu B Sridhar

Tyler C Steed

Maxim Abashin

Yeshaiahu Fainman

Eliezer Masliah

Srdjan Djurovic

Ole A Andreassen

Gabriel A Silva

David A Boas

David Kleinfeld

Richard B Buxton

Gaute T Einevoll

Anders M Dale

Anna Devor

Affiliations

Soon will be listed here.

Abstract

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

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