Historical and Current Concepts of Fibrillogenesis and In Vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2016 Jun 1

PMID 27243018

Citations 10

Authors

Robert Kisilevsky

Sara Raimondi

Vittorio Bellotti

Affiliations

Soon will be listed here.

Abstract

Historical and current concepts of in vitro fibrillogenesis are considered in the light of disorders in which amyloid is deposited at anatomic sites remote from the site of synthesis of the corresponding precursor protein. These clinical conditions set constraints on the interpretation of information derived from in vitro fibrillogenesis studies. They suggest that in addition to kinetic and thermodynamic factors identified in vitro, fibrillogenesis in vivo is determined by site specific factors most of which have yet to be identified.

Citing Articles

Serum Amyloid A Binding to Glycosaminoglycans is Synergistic with Amyloid Formation: Therapeutic Targeting in the Inflammation-linked Amyloidosis.

Jayaraman S, Urdaneta A, Fandrich M, Gursky O J Mol Biol. 2025; 437(8):169007.

PMID: 39954777 PMC: 11903164. DOI: 10.1016/j.jmb.2025.169007.

Associations Between Diabetes Mellitus and Neurodegenerative Diseases.

Szablewski L Int J Mol Sci. 2025; 26(2).

PMID: 39859258 PMC: 11765393. DOI: 10.3390/ijms26020542.

Modeling transthyretin (TTR) amyloid diseases, from monomer to amyloid fibrils.

Criddle R, Hansen L, Woodfield B, Tolley H PLoS One. 2024; 19(6):e0304891.

PMID: 38843135 PMC: 11156392. DOI: 10.1371/journal.pone.0304891.

Observation of pH-Dependent Residual Structure in the Pmel17 Repeat Domain and the Implication for Its Amyloid Formation.

Morris D, Nyenhuis D, Dean D, Strub M, Tjandra N Biochemistry. 2023; 62(22):3222-3233.

PMID: 37917797 PMC: 11822675. DOI: 10.1021/acs.biochem.3c00445.

The Role of Heme and Copper in Alzheimer's Disease and Type 2 Diabetes Mellitus.

Pal I, Dey S JACS Au. 2023; 3(3):657-681.

PMID: 37006768 PMC: 10052274. DOI: 10.1021/jacsau.2c00572.

References

Westermark P, Andersson A, Westermark G . Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. Physiol Rev. 2011; 91(3):795-826. DOI: 10.1152/physrev.00042.2009. View

BENDITT E, Eriksen N . Chemical similarity among amyloid substances associated with long standing inflammation. Lab Invest. 1972; 26(6):615-25. View

Halabelian L, Ricagno S, Giorgetti S, Santambrogio C, Barbiroli A, Pellegrino S . Class I major histocompatibility complex, the trojan horse for secretion of amyloidogenic β2-microglobulin. J Biol Chem. 2013; 289(6):3318-27. PMC: 3916536. DOI: 10.1074/jbc.M113.524157. View

Glabe C . Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging. 2006; 27(4):570-5. DOI: 10.1016/j.neurobiolaging.2005.04.017. View

Husby G, Stenstad T, Magnus J, Sletten K, Nordvag B, Marhaug G . Interaction between circulating amyloid fibril protein precursors and extracellular tissue matrix components in the pathogenesis of systemic amyloidosis. Clin Immunol Immunopathol. 1994; 70(1):2-9. DOI: 10.1006/clin.1994.1002. View

McAdam K, Elin R, Sipe J, Wolff S . Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation. J Clin Invest. 1978; 61(2):390-4. PMC: 372549. DOI: 10.1172/JCI108949. View

Noborn F, Ancsin J, Ubhayasekera W, Kisilevsky R, Li J . Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation. J Biol Chem. 2012; 287(30):25669-77. PMC: 3408152. DOI: 10.1074/jbc.M112.363895. View

Pepys M, Herbert J, Hutchinson W, Tennent G, Lachmann H, Gallimore J . Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature. 2002; 417(6886):254-9. DOI: 10.1038/417254a. View

Howie A, Brewer D . Optical properties of amyloid stained by Congo red: history and mechanisms. Micron. 2008; 40(3):285-301. DOI: 10.1016/j.micron.2008.10.002. View

10.

Ericsson L, Eriksen N, Walsh K, BENDITT E . Primary structure of duck amyloid protein A. The form deposited in tissues may be identical to its serum precursor. FEBS Lett. 1987; 218(1):11-6. DOI: 10.1016/0014-5793(87)81008-6. View

11.

Howie A, Brewer D, Howell D, Jones A . Physical basis of colors seen in Congo red-stained amyloid in polarized light. Lab Invest. 2008; 88(3):232-42. DOI: 10.1038/labinvest.3700714. View

12.

Kisilevsky R, Lemieux L, Fraser P, Kong X, Hultin P, Szarek W . Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease. Nat Med. 1995; 1(2):143-8. DOI: 10.1038/nm0295-143. View

13.

Ein D, Kimura S, TERRY W, Magnotta J, Glenner G . Amino acid sequence of an amyloid fibril protein of unknown origin. J Biol Chem. 1972; 247(17):5653-5. View

14.

Lu J, Qiang W, Yau W, Schwieters C, Meredith S, Tycko R . Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue. Cell. 2013; 154(6):1257-68. PMC: 3814033. DOI: 10.1016/j.cell.2013.08.035. View

15.

Inoue S, Kisilevsky R . In situ electron microscopy of amyloid deposits in tissues. Methods Enzymol. 1999; 309:496-509. DOI: 10.1016/s0076-6879(99)09034-5. View

16.

BUCK F, Koss M . Hepatic amyloidosis: morphologic differences between systemic AL and AA types. Hum Pathol. 1991; 22(9):904-7. DOI: 10.1016/0046-8177(91)90180-w. View

17.

Debelouchina G, Bayro M, Fitzpatrick A, Ladizhansky V, Colvin M, Caporini M . Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy. J Am Chem Soc. 2013; 135(51):19237-47. PMC: 3909659. DOI: 10.1021/ja409050a. View

18.

Kisilevsky R . Review: amyloidogenesis-unquestioned answers and unanswered questions. J Struct Biol. 2000; 130(2-3):99-108. DOI: 10.1006/jsbi.2000.4222. View

19.

Inoue S, Kuroiwa M, Kisilevsky R . AA protein in experimental murine AA amyloid fibrils: a high resolution ultrastructural and immunohistochemical study comparing aldehyde-fixed and cryofixed tissues. Amyloid. 2002; 9(2):115-25. View

20.

Hermodson M, Kuhn R, Walsh K, NEURATH H, Eriksen N, BENDITT E . Amino acid sequence of monkey amyloid protein A. Biochemistry. 1972; 11(16):2934-8. DOI: 10.1021/bi00766a002. View