Enteropathogenic E. Coli: Breaking the Intestinal Tight Junction Barrier

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2016 Jun 9

PMID 27239268

Citations 10

Authors

Anand Prakash Singh

Saima Aijaz

Affiliations

Soon will be listed here.

Abstract

Enteropathogenic E. coli (EPEC) causes acute intestinal infections in infants in the developing world. Infection typically spreads through contaminated food and water and leads to severe, watery diarrhea. EPEC attaches to the intestinal epithelial cells and directly injects virulence factors which modulate multiple signaling pathways leading to host cell dysfunction. However, the molecular mechanisms that regulate the onset of diarrhea are poorly defined. A major target of EPEC is the host cell tight junction complex which acts as a barrier and regulates the passage of water and solutes through the paracellular space. In this review, we focus on the EPEC effectors that target the epithelial barrier, alter its functions and contribute to leakage through the tight junctions.

Citing Articles

Enteropathogenic E. coli effector Map interacts with Rab13 and regulates the depletion of the tight junction proteins occludin and claudins via cathepsin B-mediated mechanisms.

Mandal A, Walling P, Qureshi S, Kansal K, Aijaz S Biol Open. 2025; 14(2).

PMID: 39912222 PMC: 11892358. DOI: 10.1242/bio.061794.

The C-terminal proline-rich repeats of Enteropathogenic E. coli effector EspF are sufficient for the depletion of tight junction membrane proteins and interactions with early and recycling endosomes.

Ansari I, Mandal A, Kansal K, Walling P, Khan S, Aijaz S Gut Pathog. 2024; 16(1):36.

PMID: 38972985 PMC: 11229284. DOI: 10.1186/s13099-024-00626-8.

Cleavage of cell junction proteins as a host invasion strategy in leptospirosis.

Kumari P, Yadav S, Sarkar S, Satheeshkumar P Appl Microbiol Biotechnol. 2024; 108(1):119.

PMID: 38204132 PMC: 10781872. DOI: 10.1007/s00253-023-12945-y.

Pathophysiology of Enteropathogenic -induced Diarrhea.

Kaur P, Dudeja P Newborn (Clarksville). 2023; 2(1):102-113.

PMID: 37388762 PMC: 10308259. DOI: 10.5005/jp-journals-11002-0056.

Intestinal barrier functions in hematologic and oncologic diseases.

Haroun E, Ashok Kumar P, Saba L, Kassab J, Ghimire K, Dutta D J Transl Med. 2023; 21(1):233.

PMID: 37004099 PMC: 10064590. DOI: 10.1186/s12967-023-04091-w.

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