Relationship Between Diffusion Tensor Imaging (DTI) Findings and Cognition Following Pediatric TBI: A Meta-Analytic Review

Overview

Journal Dev Neuropsychol

Publisher Routledge

Date 2016 May 28

PMID 27232263

Citations 20

Authors

Rachel M Roberts

Jane L Mathias

Stephen E Rose

Affiliations

Soon will be listed here.

Abstract

This study meta-analyzed research examining relationships between diffusion tensor imaging and cognition following pediatric traumatic brain injury (TBI). Data from 14 studies that correlated fractional anisotropy (FA) or apparent diffusion coefficient/mean diffusivity with cognition were analyzed. Short-term (<4 weeks post-TBI) findings were inconsistent, but, in the medium to long term, FA values for numerous large white matter tracts and the whole brain were related to cognition. However, the analyses were limited by the diversity of brain regions and cognitive outcomes that have been examined; all in relatively small samples. Moreover, additional data are needed to investigate the impact of age and injury severity on these findings.

Citing Articles

Neurobiological Insights Into Cerebral Palsy: A Review of the Mechanisms and Therapeutic Strategies.

Salomon I Brain Behav. 2024; 14(10):e70065.

PMID: 39378294 PMC: 11460637. DOI: 10.1002/brb3.70065.

Autologous bone marrow mononuclear cells to treat severe traumatic brain injury in children.

Cox Jr C, Notrica D, Juranek J, Miller J, Triolo F, Kosmach S Brain. 2024; 147(5):1914-1925.

PMID: 38181433 PMC: 11068104. DOI: 10.1093/brain/awae005.

A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age.

Obenaus A, Rodriguez-Grande B, Lee J, Dubois C, Fournier M, Cador M Acta Neuropathol Commun. 2023; 11(1):32.

PMID: 36859364 PMC: 9976423. DOI: 10.1186/s40478-023-01515-y.

Introducing advanced neuroimaging into pediatric post-arrest neuroprognostication.

Kirschen M, Vossough A Resuscitation. 2022; 182:109657.

PMID: 36481241 PMC: 10319426. DOI: 10.1016/j.resuscitation.2022.11.023.

Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury.

Abdullah A, Ahmad A, Zakaria R, Tamam S, Abd Hamid A, Chai W Front Neurol. 2022; 13:1011304.

PMID: 36303559 PMC: 9592834. DOI: 10.3389/fneur.2022.1011304.

References

Caeyenberghs K, Leemans A, Geurts M, Taymans T, Linden C, Smits-Engelsman B . Brain-behavior relationships in young traumatic brain injury patients: fractional anisotropy measures are highly correlated with dynamic visuomotor tracking performance. Neuropsychologia. 2010; 48(5):1472-82. DOI: 10.1016/j.neuropsychologia.2010.01.017. View

Mueller B, Lim K, Hemmy L, Camchong J . Diffusion MRI and its Role in Neuropsychology. Neuropsychol Rev. 2015; 25(3):250-71. PMC: 4807614. DOI: 10.1007/s11065-015-9291-z. View

McCauley S, Wilde E, Anderson V, Bedell G, Beers S, Campbell T . Recommendations for the use of common outcome measures in pediatric traumatic brain injury research. J Neurotrauma. 2011; 29(4):678-705. PMC: 3289848. DOI: 10.1089/neu.2011.1838. View

Ewing-Cobbs L, Prasad M, Swank P, Kramer L, Cox Jr C, Fletcher J . Arrested development and disrupted callosal microstructure following pediatric traumatic brain injury: relation to neurobehavioral outcomes. Neuroimage. 2008; 42(4):1305-15. PMC: 2615227. DOI: 10.1016/j.neuroimage.2008.06.031. View

Babikian T, Tong K, Galloway N, Freier-Randall M, Obenaus A, Ashwal S . Diffusion-weighted imaging predicts cognition in pediatric brain injury. Pediatr Neurol. 2009; 41(6):406-12. DOI: 10.1016/j.pediatrneurol.2009.06.002. View

Wilde E, Hunter J, Bigler E . A primer of neuroimaging analysis in neurorehabilitation outcome research. NeuroRehabilitation. 2012; 31(3):227-42. DOI: 10.3233/NRE-2012-0793. View

Caeyenberghs K, Leemans A, Geurts M, Taymans T, Vander Linden C, Smits-Engelsman B . Brain-behavior relationships in young traumatic brain injury patients: DTI metrics are highly correlated with postural control. Hum Brain Mapp. 2009; 31(7):992-1002. PMC: 6870903. DOI: 10.1002/hbm.20911. View

Adamson C, Yuan W, Babcock L, Leach J, Seal M, Holland S . Diffusion tensor imaging detects white matter abnormalities and associated cognitive deficits in chronic adolescent TBI. Brain Inj. 2013; 27(4):454-63. PMC: 4164967. DOI: 10.3109/02699052.2012.750756. View

Levin H, Wilde E, Chu Z, Yallampalli R, Hanten G, Li X . Diffusion tensor imaging in relation to cognitive and functional outcome of traumatic brain injury in children. J Head Trauma Rehabil. 2008; 23(4):197-208. PMC: 2561897. DOI: 10.1097/01.HTR.0000327252.54128.7c. View

10.

Wilde E, Chu Z, Bigler E, Hunter J, Fearing M, Hanten G . Diffusion tensor imaging in the corpus callosum in children after moderate to severe traumatic brain injury. J Neurotrauma. 2006; 23(10):1412-26. DOI: 10.1089/neu.2006.23.1412. View

11.

Duckworth J, Stevens R . Imaging brain trauma. Curr Opin Crit Care. 2010; 16(2):92-7. DOI: 10.1097/MCC.0b013e3283374900. View

12.

Pinto P, Meoded A, Poretti A, Tekes A, Huisman T . The unique features of traumatic brain injury in children. review of the characteristics of the pediatric skull and brain, mechanisms of trauma, patterns of injury, complications, and their imaging findings--part 2. J Neuroimaging. 2012; 22(2):e18-41. DOI: 10.1111/j.1552-6569.2011.00690.x. View

13.

Tasker R, Westland A, White D, Williams G . Corpus callosum and inferior forebrain white matter microstructure are related to functional outcome from raised intracranial pressure in child traumatic brain injury. Dev Neurosci. 2010; 32(5-6):374-84. DOI: 10.1159/000316806. View

14.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

15.

Treble A, Hasan K, Iftikhar A, Stuebing K, Kramer L, Cox Jr C . Working memory and corpus callosum microstructural integrity after pediatric traumatic brain injury: a diffusion tensor tractography study. J Neurotrauma. 2013; 30(19):1609-19. PMC: 3787334. DOI: 10.1089/neu.2013.2934. View

16.

Mayer A, Ling J, Yang Z, Pena A, Yeo R, Klimaj S . Diffusion abnormalities in pediatric mild traumatic brain injury. J Neurosci. 2012; 32(50):17961-9. PMC: 6621719. DOI: 10.1523/JNEUROSCI.3379-12.2012. View

17.

Beauchamp M, Beare R, Ditchfield M, Coleman L, Babl F, Kean M . Susceptibility weighted imaging and its relationship to outcome after pediatric traumatic brain injury. Cortex. 2012; 49(2):591-8. DOI: 10.1016/j.cortex.2012.08.015. View

18.

Roberts R, Mathias J, Rose S . Diffusion Tensor Imaging (DTI) findings following pediatric non-penetrating TBI: a meta-analysis. Dev Neuropsychol. 2014; 39(8):600-37. PMC: 4270261. DOI: 10.1080/87565641.2014.973958. View

19.

Niogi S, Mukherjee P . Diffusion tensor imaging of mild traumatic brain injury. J Head Trauma Rehabil. 2010; 25(4):241-55. DOI: 10.1097/HTR.0b013e3181e52c2a. View

20.

Wu T, Wilde E, Bigler E, Li X, Merkley T, Yallampalli R . Longitudinal changes in the corpus callosum following pediatric traumatic brain injury. Dev Neurosci. 2010; 32(5-6):361-73. PMC: 3073757. DOI: 10.1159/000317058. View