Sox2: Regulation of Expression and Contribution to Brain Tumors

Overview

Journal CNS Oncol

Specialty Oncology

Date 2016 May 28

PMID 27230973

Citations 24

Authors

Sheila Mansouri

Romina Nejad

Merve Karabork

Can Ekinci

Ihsan Solaroglu

Kenneth D Aldape

Gelareh Zadeh

Affiliations

Soon will be listed here.

Abstract

Tumors of the CNS are composed of a complex mixture of neoplastic cells, in addition to vascular, inflammatory and stromal components. Similar to most other tumors, brain tumors contain a heterogeneous population of cells that are found at different stages of differentiation. The cancer stem cell hypothesis suggests that all tumors are composed of subpopulation of cells with stem-like properties, which are capable of self-renewal, display resistance to therapy and lead to tumor recurrence. One of the most important transcription factors that regulate cancer stem cell properties is SOX2. In this review, we focus on SOX2 and the complex network of signaling molecules and transcription factors that regulate its expression and function in brain tumor initiating cells. We also highlight important findings in the literature about the role of SOX2 in glioblastoma and medulloblastoma, where it has been more extensively studied.

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