Association Between Perinatal Hypoxic-Ischemic Conditions and Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis

Overview

Journal J Child Neurol

Specialties Neurology
Pediatrics

Date 2016 May 28

PMID 27229008

Citations 23

Authors

Tingting Zhu

Jing Gan

Jichong Huang

Yafei Li

Yi Qu

Dezhi Mu

Affiliations

Soon will be listed here.

Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder worldwide, but its etiology is still not fully understood. Previous studies have reported that perinatal hypoxic-ischemic conditions may be a potential cause of ADHD.

Methods: An online search of potential English studies published before September 2015 was conducted using the PsycINFO, EMBASE, Web of Science, and PubMed databases. The combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models.

Results: Ten studies were included, with 45 821 cases and 9 207 363 controls. The metaresults found that the following were associated with ADHD: preeclampsia (OR 1.31; 95% CI 1.26-1.37), an Apgar score <7 at 5 minutes (OR 1.31; 95% CI 1.12-1.54), breech/transverse presentations (OR 1.14; 95% CI 1.06-1.23), and a prolapsed/nuchal cord (OR 1.10; 95% CI 1.06-1.15).

Conclusion: Our results support that perinatal hypoxia-ischemia may contribute to ADHD. However, more clinical studies are warranted.

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