MiR-135a Inhibits the Invasion of Cancer Cells Via Suppression of ERRα

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 May 27

PMID 27227989

Citations 28

Authors

Violaine Tribollet

Bruno Barenton

Auriane Kroiss

Severine Vincent

Ling Zhang

Christelle Forcet

Catherine Cerutti

Severine Perian

Nathalie Allioli

Jacques Samarut

Jean-Marc Vanacker

Affiliations

Soon will be listed here.

Abstract

MicroRNA-135a (miR-135a) down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors) as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Estrogen-Related Receptor α (ERRα), an orphan member of the nuclear receptor family. Indeed high expression of ERRα correlates with poor prognosis in breast and prostate cancers, and the receptor promotes various traits of cancer aggressiveness including cell invasion. Here we show that miR-135a down-regulates the expression of ERRα through specific sequences of its 3'UTR. As a consequence miR-135a also reduces the expression of downstream targets of ERRα. miR-135a also decreases cell invasive potential in an ERRα-dependent manner. Our results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRα expression, resulting in increased cell invasion capacities.

Citing Articles

IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression.

Zhu X, Dong W, Zhang M J Cell Commun Signal. 2024; 18(1):e12016.

PMID: 38545258 PMC: 10964940. DOI: 10.1002/ccs3.12016.

ERRα: unraveling its role as a key player in cell migration.

Vanacker J, Forcet C Oncogene. 2023; 43(6):379-387.

PMID: 38129506 DOI: 10.1038/s41388-023-02899-w.

Multifaceted Transcriptional Network of Estrogen-Related Receptor Alpha in Health and Disease.

Cerutti C, Shi J, Vanacker J Int J Mol Sci. 2023; 24(5).

PMID: 36901694 PMC: 10002233. DOI: 10.3390/ijms24054265.

A review on the importance of miRNA-135 in human diseases.

Kadkhoda S, Eslami S, Hussen B, Ghafouri-Fard S Front Genet. 2022; 13:973585.

PMID: 36147505 PMC: 9486161. DOI: 10.3389/fgene.2022.973585.

MiRNA expression deregulation correlates with the Oncotype DX DCIS score.

Loudig O, Mitchell M, Ben-Dov I, Liu C, Fineberg S Breast Cancer Res. 2022; 24(1):62.

PMID: 36096802 PMC: 9469592. DOI: 10.1186/s13058-022-01558-4.

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