Experimental Infection of Rio Mamore Hantavirus in Sigmodontinae Rodents

Overview

Journal Mem Inst Oswaldo Cruz

Specialties Parasitology
Tropical Medicine

Date 2016 May 26

PMID 27223653

Citations 1

Authors

William Marciel de Souza

Alex Martins Machado

Luiz Tadeu Moraes Figueiredo

Affiliations

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Abstract

This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.

Citing Articles

The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future.

Madrieres S, Castel G, Murri S, Vulin J, Marianneau P, Charbonnel N Viruses. 2019; 11(7).

PMID: 31331096 PMC: 6669540. DOI: 10.3390/v11070664.

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