Dual PET and Near-Infrared Fluorescence Imaging Probes As Tools for Imaging in Oncology

Overview

Journal AJR Am J Roentgenol

Specialties Oncology
Radiology

Date 2016 May 26

PMID 27223168

Citations 23

Authors

Fei-Fei An

Mark Chan

Harikrishna Kommidi

Richard Ting

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this article is to summarize advances in PET fluorescence resolution, agent design, and preclinical imaging that make a growing case for clinical PET fluorescence imaging.

Conclusion: Existing SPECT, PET, fluorescence, and MRI contrast imaging techniques are already deeply integrated into the management of cancer, from initial diagnosis to the observation and management of metastases. Combined positron-emitting fluorescent contrast agents can convey new or substantial benefits that improve on these proven clinical contrast agents.

Citing Articles

Multimodal laparoscopic coincidence gamma imaging system for near-infrared fluorescence guided surgery: a preclinical study.

Song S, Hong S, Lee H, Kang H, Han Y J Med Imaging (Bellingham). 2023; 10(3):033505.

PMID: 37351312 PMC: 10284170. DOI: 10.1117/1.JMI.10.3.033505.

Multimodality PET and Near-Infrared Fluorescence Intraoperative Imaging of CEA-Positive Colorectal Cancer.

Lwin T, Minnix M, Li L, Sherman A, Hong T, Wong J Mol Imaging Biol. 2023; 25(4):727-734.

PMID: 37341873 PMC: 10333401. DOI: 10.1007/s11307-023-01831-8.

Asymmetric rotaxanes as dual-modality supramolecular imaging agents for targeting cancer biomarkers.

dOrchymont F, Holland J Commun Chem. 2023; 6(1):107.

PMID: 37264077 PMC: 10235045. DOI: 10.1038/s42004-023-00906-5.

A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity.

Pandurang T, Cacaccio J, Durrani F, Dukh M, Alsaleh A, Sajjad M Molecules. 2023; 28(9).

PMID: 37175191 PMC: 10180080. DOI: 10.3390/molecules28093782.

Modular Synthesis of Peptide-Based Single- and Multimodal Targeted Molecular Imaging Agents.

Schmitthenner H, Barrett T, Beach S, Heese L, Weidman C, Dobson D ACS Appl Bio Mater. 2022; 4(7):5435-5448.

PMID: 35006725 PMC: 9633131. DOI: 10.1021/acsabm.1c00157.

References

Vera D, Wallace A, Hoh C . [(99m)Tc]MAG(3)-mannosyl-dextran: a receptor-binding radiopharmaceutical for sentinel node detection. Nucl Med Biol. 2001; 28(5):493-8. DOI: 10.1016/s0969-8051(01)00218-9. View

Hall M, Kwon S, Robinson H, Lachance P, Azhdarinia A, Ranganathan R . Imaging prostate cancer lymph node metastases with a multimodality contrast agent. Prostate. 2011; 72(2):129-46. DOI: 10.1002/pros.21413. View

Liu Z, Radtke M, Wong M, Lin K, Yapp D, Perrin D . Dual mode fluorescent (18)F-PET tracers: efficient modular synthesis of rhodamine-[cRGD]2-[(18)F]-organotrifluoroborate, rapid, and high yielding one-step (18)F-labeling at high specific activity, and correlated in vivo PET imaging and ex vivo.... Bioconjug Chem. 2014; 25(11):1951-62. DOI: 10.1021/bc5003357. View

Paudyal P, Paudyal B, Iida Y, Oriuchi N, Hanaoka H, Tominaga H . Dual functional molecular imaging probe targeting CD20 with PET and optical imaging. Oncol Rep. 2009; 22(1):115-9. DOI: 10.3892/or_00000413. View

Zheng Q, Juette M, Jockusch S, Wasserman M, Zhou Z, Altman R . Ultra-stable organic fluorophores for single-molecule research. Chem Soc Rev. 2013; 43(4):1044-56. PMC: 3946787. DOI: 10.1039/c3cs60237k. View

Roesch F . Maturation of a key resource - the germanium-68/gallium-68 generator: development and new insights. Curr Radiopharm. 2012; 5(3):202-11. DOI: 10.2174/1874471011205030202. View

Lindner S, Michler C, Leidner S, Rensch C, Wangler C, Schirrmacher R . Synthesis and in vitro and in vivo evaluation of SiFA-tagged bombesin and RGD peptides as tumor imaging probes for positron emission tomography. Bioconjug Chem. 2014; 25(4):738-49. DOI: 10.1021/bc400588e. View

Perez K, Walsh R, Brilliant K, Noble L, Yakirevich E, Breese V . Heterogeneity of colorectal cancer (CRC) in reference to KRAS proto-oncogene utilizing WAVE technology. Exp Mol Pathol. 2013; 95(1):74-82. PMC: 4015467. DOI: 10.1016/j.yexmp.2013.01.004. View

Garg P, Garg S, Zalutsky M . Fluorine-18 labeling of monoclonal antibodies and fragments with preservation of immunoreactivity. Bioconjug Chem. 1991; 2(1):44-9. DOI: 10.1021/bc00007a008. View

10.

Weissleder R, Ntziachristos V . Shedding light onto live molecular targets. Nat Med. 2003; 9(1):123-8. DOI: 10.1038/nm0103-123. View

11.

Hong H, Zhang Y, Severin G, Yang Y, Engle J, Niu G . Multimodality imaging of breast cancer experimental lung metastasis with bioluminescence and a monoclonal antibody dual-labeled with 89Zr and IRDye 800CW. Mol Pharm. 2012; 9(8):2339-49. PMC: 3500677. DOI: 10.1021/mp300277f. View

12.

Wu S, Lee I, Ghoroghchian P, Frail P, Zheng G, Glickson J . Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores. Bioconjug Chem. 2005; 16(3):542-50. DOI: 10.1021/bc0497416. View

13.

Flavell R, Kothari P, Bar-Dagan M, Synan M, Vallabhajosula S, Friedman J . Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. J Am Chem Soc. 2008; 130(28):9106-12. DOI: 10.1021/ja801666z. View

14.

Vera D, Wisner E, Stadalnik R . Sentinel node imaging via a nonparticulate receptor-binding radiotracer. J Nucl Med. 1997; 38(4):530-5. View

15.

Seibold U, Wangler B, Schirrmacher R, Wangler C . Bimodal imaging probes for combined PET and OI: recent developments and future directions for hybrid agent development. Biomed Res Int. 2014; 2014:153741. PMC: 4009187. DOI: 10.1155/2014/153741. View

16.

Deri M, Zeglis B, Francesconi L, Lewis J . PET imaging with ⁸⁹Zr: from radiochemistry to the clinic. Nucl Med Biol. 2012; 40(1):3-14. PMC: 3517725. DOI: 10.1016/j.nucmedbio.2012.08.004. View

17.

An C, Shi Y, Li P, Hu X, Gan Y, Stetler R . Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair. Prog Neurobiol. 2013; 115:6-24. PMC: 4014303. DOI: 10.1016/j.pneurobio.2013.12.002. View

18.

Paulus A, Desai P, Carney B, Carlucci G, Reiner T, Brand C . Development of a clickable bimodal fluorescent/PET probe for in vivo imaging. EJNMMI Res. 2015; 5(1):120. PMC: 4540712. DOI: 10.1186/s13550-015-0120-4. View

19.

Pascu S, Waghorn P, Conry T, Betts H, Dilworth J, Churchill G . Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging. Dalton Trans. 2007; (43):4988-97. DOI: 10.1039/b705227h. View

20.

Zou Z, Zhang H, Roditi G, Leiner T, Kucharczyk W, Prince M . Nephrogenic systemic fibrosis: review of 370 biopsy-confirmed cases. JACC Cardiovasc Imaging. 2011; 4(11):1206-16. DOI: 10.1016/j.jcmg.2011.08.013. View