A Linkage Group with FRA16B (the Fragile Site at 16q22.1)

Overview

Journal Hum Genet

Specialty Genetics

Date 1989 May 1

PMID 2722188

Citations 2

Authors

J C Mulley

V J Hyland

A Fratini

L J Bates

A K Gedeon

G R Sutherland

Affiliations

Soon will be listed here.

Abstract

Polymorphic DNA markers located in bands 16q13, 16q21 and 16q22 were examined for recombination with FRA16B, the fragile site at 16q22.100. A tight linkage cluster D16S10-FRA16B-D16S4-HP was established. There were no recombinants (theta = 0.0, z = 8.3) between D16S10 and D16S4, which flank FRA16B. The markers D16S10 and D16S4 are in close proximity on the genetic map and delineate a small chromosomal segment, which contains the distamycin A-inducible fragile site.

Citing Articles

A new folate sensitive fragile site at 1p21.3.

Baker E, Sutherland G J Med Genet. 1991; 28(5):356-7.

PMID: 1865478 PMC: 1016860. DOI: 10.1136/jmg.28.5.356.

Construction of a map of chromosome 16 by using radiation hybrids.

Ceccherini I, Romeo G, Lawrence S, Breuning M, Harris P, Himmelbauer H Proc Natl Acad Sci U S A. 1992; 89(1):104-8.

PMID: 1729675 PMC: 48184. DOI: 10.1073/pnas.89.1.104.

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