MicroRNA-125b Promotes Invasion and Metastasis of Gastric Cancer by Targeting STARD13 and NEU1

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 May 26

PMID 27220320

Citations 30

Authors

Shuai Chang

Shicai He

Guanglin Qiu

Jing Lu

Jin Wang

Junsong Liu

Lin Fan

Wei Zhao

Xiangming Che

Affiliations

Soon will be listed here.

Abstract

MicroRNAs have been documented playing key roles in cancer development and progression. Here, we investigate the role of miR-125b in gastric cancer metastasis. We found that the expression of miR-125b was up-regulated in gastric cancer tissue specimens compared with their corresponding nontumorous tissues, and the up-regulated miR-125b level was significantly associated with TNM stage and lymph node-metastasis. Overexpression of miR-125b promoted gastric cancer cell migration and invasion in vitro and metastasis in vivo. STARD13 and NEU1 were identified as direct target genes of miR-125b by luciferase assays, and they were involved in the cell migration and invasion regulated by miR-125b in gastric cancer. Taken together, miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer.

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