The Predictors Study: Development and Baseline Characteristics of The Predictors 3 Cohort

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2016 May 25

PMID 27219818

Citations 11

Authors

Yaakov Stern

Yian Gu

Stephanie Cosentino

Martina Azar

Siobhan Lawless

Oksana Tatarina

Affiliations

Soon will be listed here.

Abstract

Introduction: The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer's disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort.

Methods: Patients with prevalent or incident AD and individuals at-risk for developing AD were selected from the North Manhattan community and followed annually with instruments comparable to those used in the original two Predictors cohorts.

Results: The original Predictors cohorts were clinic based and racially/ethnically homogenous (94% white, 6% black; 3% Hispanic). In contrast, the 274 elders in this cohort are community-based and ethnically diverse (39% white, 40% black, 21% other; 78% Hispanic). Confirming previous observations, psychotic features were associated with poorer function and mental status and extrapyramidal signs with poorer function.

Discussion: This new cohort will allow us to test observations made in our original clinic-based cohorts in patients that may be more representative of the general community.

Citing Articles

Neuropsychiatric Symptoms and Trajectories of Dependence and Cognition in a Sample of Community-dwelling Older Adults with Dementia.

Kociolek A, Fernandez K, Hernandez M, Jin Z, Cosentino S, Zhu C Curr Alzheimer Res. 2023; 20(6):409-419.

PMID: 37694796 PMC: 10726418. DOI: 10.2174/1567205020666230908163414.

Validation of a Multivariate Prediction Model of the Clinical Progression of Alzheimer's Disease in a Community-Dwelling Multiethnic Cohort.

Stallard E, Kociolek A, Jin Z, Ryu H, Lee S, Cosentino S J Alzheimers Dis. 2023; 95(1):93-117.

PMID: 37482990 PMC: 10528912. DOI: 10.3233/JAD-220811.

Neuropsychological Predictors of Severe Functional Dependency in a Multiethnic Community Cohort of Individuals with Alzheimer's Disease.

Carcamo J, Kociolek A, Fernandez K, Gu Y, Zhu C, Stern Y J Alzheimers Dis. 2021; 83(2):539-544.

PMID: 34366333 PMC: 10131178. DOI: 10.3233/JAD-210019.

Validation and demonstration of a new comprehensive model of Alzheimer's disease progression.

Stern Y, Stallard E, Kinosian B, Zhu C, Cosentino S, Jin Z Alzheimers Dement. 2021; 17(10):1698-1708.

PMID: 33991041 PMC: 8818260. DOI: 10.1002/alz.12336.

Semiparametric regression analysis of bivariate censored events in a family study of Alzheimer's disease.

Gao F, Zeng D, Wang Y Biostatistics. 2021; 24(1):32-51.

PMID: 33948627 PMC: 9748583. DOI: 10.1093/biostatistics/kxab014.

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