Decreased Circulating Levels of Spexin in Obese Children

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2016 May 25

PMID 27218269

Citations 37

Authors

Seema Kumar

Jobayer Hossain

Nicole Nader

Roxana Aguirre

Swetha Sriram

P Babu Balagopal

Affiliations

Soon will be listed here.

Abstract

Context: Spexin is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in children.

Objective: The aim of the current study was to determine the potential role of Spexin in obese children and explore its relationships with various cardiometabolic risk factors.

Design And Participants: This was a cross-sectional study composed of 69 children (51 obese and 18 normal weight; age 15.3 ± 0.26 y).

Outcome Measures: Spexin was measured using a specific enzyme-linked immunosorbent assay. Leptin, total and high-molecular-weight adiponectin, IL-6, high-sensitivity C-reactive protein, glucose, and insulin were also measured. Mann-Whitney U test, Pearson and Spearman rank correlations, logistic regression, and cluster analysis were used for the analysis and interpretation of the data.

Results: Spexin levels were significantly lower in obese vs normal-weight children, median(IQR) (0.33 ng/mL [0.27-0.44] vs 0.42 ng/mL [0.33-0.55]; P = .024), but did not correlate with other adipokines and/or insulin and glucose levels. Ordinal categorical variables of Spexin showed a strictly reverse association of obesity with the level of Spexin. Cluster analysis of Spexin and body mass index z score resulted in splitting the participants into normal-weight and obese-weight groups with high accuracy.

Conclusions: Lower circulating levels of Spexin in obese children compared with their normal-weight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity. The clinical significance of these findings needs additional investigation.

Citing Articles

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Role of Spexin in White Adipose Tissue Thermogenesis under Basal and Cold-Stimulated Conditions.

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Spexin-based galanin receptor 2 agonist improves renal injury in mice with type 2 diabetes.

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Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.

Gajewska J, Szamotulska K, Klemarczyk W, Chelchowska M, Strucinska M, Ambroszkiewicz J Nutrients. 2023; 15(5).

PMID: 36904239 PMC: 10005720. DOI: 10.3390/nu15051240.

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