JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2016 May 25

PMID 27216293

Citations 15

Authors

Kazunori Gomi

Michelle R Staudt

Jacqueline Salit

Robert J Kaner

Jonna Heldrich

Allison M Rogalski

Vanessa Arbelaez

Ronald G Crystal

Matthew S Walters

Affiliations

Soon will be listed here.

Abstract

Basal cells (BC) are the stem/progenitor cells of the human airway epithelium capable of differentiating into secretory and ciliated cells. Notch signaling activation increases BC differentiation into secretory cells, but the role of individual Notch ligands in regulating this process in the human airway epithelium is largely unknown. The objective of this study was to define the role of the Notch ligand JAG1 in regulating human BC differentiation. JAG1 over-expression in BC increased secretory cell differentiation, with no effect on ciliated cell differentiation. Conversely, knockdown of JAG1 decreased expression of secretory cell genes. These data demonstrate JAG1-mediated Notch signaling regulates differentiation of BC into secretory cells.

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