Six New Physalins from Physalis Alkekengi Var. Franchetii and Their Cytotoxicity and Antibacterial Activity

Overview

Journal Fitoterapia

Publisher Elsevier

Specialties Pharmacology
Rehabilitation Medicine

Date 2016 May 25

PMID 27215128

Citations 11

Authors

Ye-Kun Yang

Si-Da Xie

Wan-Xuan Xu

Yin Nian

Xiao-Ling Liu

Xing-Rong Peng

Zhong-Tao Ding

Ming-Hua Qiu

Affiliations

Soon will be listed here.

Abstract

Six new physalin steroids, 7β-methoxylisophysalin B (1), 7β-methoxylphysalin C (2), physalin V (3), physalin VI (4), physalin VII (5), isophysalin I (6), together with 20 known physalins (7-26) were isolated from calyces of Physalis alkekengi var. franchetii. Structures of the new compounds were revealed through 1D and 2D NMR and mass spectroscopic methods. Compounds 1-26 were evaluated for cytotoxicity against human HL-60, SMMC-7721, A-549, MCF-7 and SW-480, and the results indicated that compounds 8, 11, and 14 displayed potent cytotoxicities (IC50<5μM) in vitro. Further antibacterial assay indicated that compounds 8, 14, and 19 showed high antibacterial activities against Bacillus subtilis and Escherichia coli.

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