[Pathogens and Clinical Characteristics of Bacterial Infection in Hematology Department Between 2010 and 2014]

Overview

Journal Zhonghua Xue Ye Xue Za Zhi

Specialty Hematology

Date 2016 May 24

PMID 27210872

Citations 2

Authors

L Zhang

H W Lu

H L Liu

X Y Zhu

B L Tang

C C Zheng

H Z Yang

L Q Geng

K Y Ding

X B Wang

Y S Han

X Liu

J S Wu

W W Zhu

X Y Cai

Z M Sun

Affiliations

Soon will be listed here.

Abstract

Objective: To analyze the characteristics of distribution and drug resistance of bacterial infection in several different parts of hematology department inpatients of Anhui Provincial Hospital from January 2010 to December 2014, including patients who had received hematopoietic stem cell transplantation (HSCT).

Methods: Anti-microbial susceptibility test was done by Kirby-Bauer method and automated systems and the data were analysed by WHONET 5.6 software.

Results: A total of 3 312 copies of inspection samples were analyzed, including 2 716 (82%) blood samples and other 596 specimens (18%). 634 bacterial strains were isolated from 3 312 samples (19.14%) including 488 samples (76.97%) from blood culture. 427 (67.35%) bacterial strains were gram-negative, and the other 207 (32.65%) were gram-positive. Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were most common gram-negative bacterial and the resistant rates to imipenem were 0.8%, 11.8% and 3.3%, respectively. Detection rates of Extended-spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae were 83.9% and 75.0%, respectively. At the same time, Coagulase negative Staphylococcus, Streptococcus and Enterococcus were most common kinds of gram-positive bacteria. Methicillin-resistant coagulase negative staphylococcus accounted for 65.9% antibiotic resistance. No vancomycin and/or linezolid and/or tigecycline resistant strains of Staphylococcus spp. and Enterococcus spp. were found in those patients.

Conclusion: Patients with hematology diseases had a higher risk of bacterial infections, mainly caused by Gram-negative bacteria. There are different distributions of bacterial in different wards.

Citing Articles

A Novel Risk Predictive Scoring Model for Predicting Subsequent Infection After Carbapenem-Resistant Gram-Negative Bacteria Colonization in Hematological Malignancy Patients.

Wu Q, Qian C, Yin H, Liu F, Wu Y, Li W Front Oncol. 2022; 12:897479.

PMID: 35651791 PMC: 9150434. DOI: 10.3389/fonc.2022.897479.

The incidence, risk factors and outcomes of early bloodstream infection in patients with malignant hematologic disease after unrelated cord blood transplantation: a retrospective study.

Ge J, Yang T, Zhang L, Zhang X, Zhu X, Tang B BMC Infect Dis. 2018; 18(1):654.

PMID: 30545330 PMC: 6293544. DOI: 10.1186/s12879-018-3575-x.

References

Andersen N, Moller J, Peterslund N . Piperacillin-resistant Escherichia coli bacteraemia: relation to empiric therapy and clinical outcome. Scand J Infect Dis. 2005; 37(2):90-5. DOI: 10.1080/00365540510027219. View

Satlin M, Calfee D, Chen L, Fauntleroy K, Wilson S, Jenkins S . Emergence of carbapenem-resistant Enterobacteriaceae as causes of bloodstream infections in patients with hematologic malignancies. Leuk Lymphoma. 2012; 54(4):799-806. DOI: 10.3109/10428194.2012.723210. View

Satlin M, Jenkins S, Chen L, Helfgott D, Feldman E, Kreiswirth B . Septic shock caused by Klebsiella pneumoniae carbapenemase-producing Enterobacter gergoviae in a neutropenic patient with leukemia. J Clin Microbiol. 2013; 51(8):2794-6. PMC: 3719649. DOI: 10.1128/JCM.00004-13. View

Rodriguez-Bano J, Pascual A . Clinical significance of extended-spectrum beta-lactamases. Expert Rev Anti Infect Ther. 2008; 6(5):671-83. DOI: 10.1586/14787210.6.5.671. View

Wang F, Lin M, Liu C . Bacteremia in patients with hematological malignancies. Chemotherapy. 2005; 51(2-3):147-53. DOI: 10.1159/000085623. View

Yang J, Luo Y, Cui S, Wang W, Han L . Diverse phenotypic and genotypic characterization among clinical Klebsiella pneumoniae and Escherichia coli isolates carrying plasmid-mediated quinolone resistance determinants. Microb Drug Resist. 2011; 17(3):363-7. DOI: 10.1089/mdr.2011.0034. View

Han T, Huang X, Liu K, Liu D, Chen H, Han W . [Blood stream infections during agranulocytosis period after hematopoietic stem cell transplantation in one single center]. Zhonghua Nei Ke Za Zhi. 2011; 50(8):654-8. View

El-Mahallawy H, Samir I, Fattah R, Kadry D, El-Kholy A . Source, pattern and antibiotic resistance of blood stream infections in hematopoietic stem cell transplant recipients. J Egypt Natl Canc Inst. 2014; 26(2):73-7. DOI: 10.1016/j.jnci.2013.12.001. View

Keng M, Sekeres M . Febrile neutropenia in hematologic malignancies. Curr Hematol Malig Rep. 2013; 8(4):370-8. DOI: 10.1007/s11899-013-0171-4. View

10.

Hammerstrom J, Roym A, Gran F . [Bacteremia in hematological malignant disorders]. Tidsskr Nor Laegeforen. 2008; 128(15):1655-9. View

11.

Shibata H, Yamane T, Sakamoto E, Nakamae H, Ohta K, Hino M . [Clinical analysis of antibiotic treatment for febrile neutropenia]. Jpn J Antibiot. 2005; 58(4):382-7. View

12.

Cho S, Lee D, Choi S, Kwon J, Kim S, Choi J . Impact of vancomycin resistance on mortality in neutropenic patients with enterococcal bloodstream infection: a retrospective study. BMC Infect Dis. 2013; 13:504. PMC: 3870976. DOI: 10.1186/1471-2334-13-504. View

13.

Samonis G, Vardakas K, Maraki S, Tansarli G, Dimopoulou D, Kofteridis D . A prospective study of characteristics and outcomes of bacteremia in patients with solid organ or hematologic malignancies. Support Care Cancer. 2013; 21(9):2521-6. DOI: 10.1007/s00520-013-1816-5. View