Fabrication, Characterization, and in Vitro Evaluation of Silver-containing Arabinoxylan Foams As Antimicrobial Wound Dressing

Overview

Journal J Biomed Mater Res A

Specialty Biomedical Engineering

Date 2016 May 21

PMID 27199211

Citations 5

Authors

Donald C Aduba Jr

Seon-Sook An

Gretchen S Selders

Juan Wang

W Andrew Yeudall

Gary L Bowlin

Todd Kitten

Hu Yang

Affiliations

Soon will be listed here.

Abstract

Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2456-2465, 2016.

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