Isolation and Primary Structure of Rat Secretin

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1989 Apr 28

PMID 2719704

Citations 5

Authors

D Gossen

A VANDERMEERS

J RATHE

A Cauvin

P Robberecht

J Christophe

Affiliations

Soon will be listed here.

Abstract

A major form of rat secretin was purified to homogeneity from small intestine, being detected with a porcine secretin radioimmunoassay throughout 7 chromatographic steps. The sequence of the heptacosapeptide amide H-S-D-G-T-F-T-S-E-L-S-R-L-Q-D-S-A-R-L-Q-R-L-L-Q-G-L-V-NH2 shows that rat secretin has a glutamine residue in position 14 instead of arginine as in pig secretin.

Citing Articles

Involvement of Secretin in the Control of Cell Survival and Synaptic Plasticity in the Central Nervous System.

Wang L, Zhang L Front Neurosci. 2020; 14:387.

PMID: 32435180 PMC: 7218122. DOI: 10.3389/fnins.2020.00387.

Identification and localization of secretin and secretin receptor mRNAs in rat testis.

Monts B, Lee W, Breyer P, Russell L, Rivkees S, Pescovitz O Endocrine. 2010; 3(7):505-10.

PMID: 21153206 DOI: 10.1007/BF02738825.

Secretin as a neuropeptide.

Ng S, Yung W, Chow B Mol Neurobiol. 2002; 26(1):97-107.

PMID: 12392059 DOI: 10.1385/MN:26:1:097.

Processing of prosecretin: isolation of a secretin precursor from porcine intestine.

Gafvelin G, Jornvall H, Mutt V Proc Natl Acad Sci U S A. 1990; 87(17):6781-5.

PMID: 2395872 PMC: 54621. DOI: 10.1073/pnas.87.17.6781.

Secretin: structure of the precursor and tissue distribution of the mRNA.

Kopin A, Wheeler M, Leiter A Proc Natl Acad Sci U S A. 1990; 87(6):2299-303.

PMID: 2315322 PMC: 53674. DOI: 10.1073/pnas.87.6.2299.