The Iron Homeostasis Network and Hepatitis C Virus - a New Challenge in the Era of Directly Acting Antivirals

Overview

Journal Virulence

Specialty Microbiology

Date 2016 May 20

PMID 27196953

Citations 4

Authors

Katarzyna Sikorska

Affiliations

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Citing Articles

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References

Gotte M, Feld J . Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights. Nat Rev Gastroenterol Hepatol. 2016; 13(6):338-51. DOI: 10.1038/nrgastro.2016.60. View

Cacoub P, Gragnani L, Comarmond C, Zignego A . Extrahepatic manifestations of chronic hepatitis C virus infection. Dig Liver Dis. 2014; 46 Suppl 5:S165-73. DOI: 10.1016/j.dld.2014.10.005. View

Aoki C, Rossaro L, Ramsamooj R, Brandhagen D, Burritt M, Bowlus C . Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. J Clin Gastroenterol. 2004; 39(1):71-4. View

Fujita N, Sugimoto R, Urawa N, Araki J, Mifuji R, Yamamoto M . Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C. J Gastroenterol Hepatol. 2007; 22(11):1886-93. DOI: 10.1111/j.1440-1746.2006.04759.x. View

. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 385(9963):117-71. PMC: 4340604. DOI: 10.1016/S0140-6736(14)61682-2. View

Wroblewska A, Bernat A, Woziwodzka A, Markiewicz J, Romanowski T, Bielawski K . Interferon lambda polymorphisms associate with body iron indices and hepatic expression of interferon-responsive long non-coding RNA in chronic hepatitis C. Clin Exp Med. 2016; 17(2):225-232. PMC: 5403869. DOI: 10.1007/s10238-016-0423-4. View

Theurl I, Zoller H, Obrist P, Datz C, Bachmann F, Elliott R . Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3. J Infect Dis. 2004; 190(4):819-25. DOI: 10.1086/422261. View

Nishina S, Hino K, Korenaga M, Vecchi C, Pietrangelo A, Mizukami Y . Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology. 2008; 134(1):226-38. DOI: 10.1053/j.gastro.2007.10.011. View

Tai A, Benita Y, Peng L, Kim S, Sakamoto N, Xavier R . A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe. 2009; 5(3):298-307. PMC: 2756022. DOI: 10.1016/j.chom.2009.02.001. View

10.

Fillebeen C, Pantopoulos K . Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells. J Hepatol. 2010; 53(6):995-9. DOI: 10.1016/j.jhep.2010.04.044. View

11.

Verma R, Khanna P, Chawla S . Hepatitis C vaccine. Need of the hour. Hum Vaccin Immunother. 2014; 10(7):1927-9. PMC: 4186052. DOI: 10.4161/hv.29033. View

12.

Foka P, Dimitriadis A, Karamichali E, Kyratzopoulou E, Giannimaras D, Koskinas J . Alterations in the iron homeostasis network: A driving force for macrophage-mediated hepatitis C virus persistency. Virulence. 2016; 7(6):679-90. PMC: 4991317. DOI: 10.1080/21505594.2016.1175700. View

13.

Thomas D . Global control of hepatitis C: where challenge meets opportunity. Nat Med. 2013; 19(7):850-8. PMC: 4937625. DOI: 10.1038/nm.3184. View

14.

Liu H, Trinh T, Dong H, Keith R, Nelson D, Liu C . Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus. PLoS One. 2012; 7(10):e46631. PMC: 3478283. DOI: 10.1371/journal.pone.0046631. View

15.

Bartolomei G, Cevik R, Marcello A . Modulation of hepatitis C virus replication by iron and hepcidin in Huh7 hepatocytes. J Gen Virol. 2011; 92(Pt 9):2072-2081. DOI: 10.1099/vir.0.032706-0. View

16.

Heim M . Innate immunity and HCV. J Hepatol. 2012; 58(3):564-74. DOI: 10.1016/j.jhep.2012.10.005. View

17.

Ganz T, Nemeth E . Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012; 1823(9):1434-43. PMC: 4048856. DOI: 10.1016/j.bbamcr.2012.01.014. View

18.

Sikorska K, Romanowski T, Stalke P, Izycka Swieszewska E, Bielawski K . Association of hepcidin mRNA expression with hepatocyte iron accumulation and effects of antiviral therapy in chronic hepatitis C infection. Hepat Mon. 2015; 14(11):e21184. PMC: 4286710. DOI: 10.5812/hepatmon.21184. View

19.

Kim A, Onofrey S, Church D . An epidemiologic update on hepatitis C infection in persons living with or at risk of HIV infection. J Infect Dis. 2013; 207 Suppl 1:S1-6. PMC: 3565593. DOI: 10.1093/infdis/jis927. View

20.

Shan Y, Lambrecht R, Bonkovsky H . Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey. Clin Infect Dis. 2005; 40(6):834-41. DOI: 10.1086/428062. View