Immunohistochemical Expression of Budding Uninhibited by Benzimidazole Related 1 in Leukoplakia and Oral Squamous Cell Carcinoma

Overview

Journal J Oral Maxillofac Pathol

Date 2016 May 20

PMID 27194865

Citations 2

Authors

Taneeru Sravya

Yeluri Sivaranjani

Guttikonda Venkateswara Rao

Affiliations

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Abstract

Background: Budding uninhibited by benzimidazole related 1 (BUBR1) is an important protein in the mitotic spindle assembly checkpoint. Alterations in expression of BUBR1 have been reported in many premalignant and malignant lesions.

Aim: To compare the expression of BUBR1 with respect to the normal mucosa and degree of dysplasia in oral leukoplakia (OL) and also with respect to different histopathological grades of oral squamous cell carcinoma (OSCC).

Materials And Methods: Neutral buffered formalin-fixed and paraffin-embedded biopsy specimens 30 each of normal, OL and OSCC tissue were included in this study. The expression of BUBR1 was detected using immunohistochemistry (IHC). The scores obtained were subjected to ANOVA test.

Results: Significant correlation was found in immunostaining between normal, dysplasia and OSCC groups with a P value of 0.00001. The expression of BUBR1 was significant when compared with different degrees of dysplasia and in different histopathological grades of OSCC with a P value of 0.00001.

Conclusion: Higher IHC scores were obtained with increased histopathological grades of OL and OSCC suggesting its role as a prognostic indicator.

Citing Articles

A meta-analysis reveals the protein profile associated with malignant transformation of oral leukoplakia.

Normando A, Santana Dos Santos E, Sa J, Busso-Lopes A, De Rossi T, Malta de Sa Patroni F Front Oral Health. 2023; 4:1088022.

PMID: 36923449 PMC: 10008949. DOI: 10.3389/froh.2023.1088022.

Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study.

Monteiro L, Silva P, Delgado L, Amaral B, Garces F, Salazar F Med Oral Patol Oral Cir Bucal. 2021; 26(6):e719-e728.

PMID: 34704983 PMC: 8601638. DOI: 10.4317/medoral.24511.

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