Transitional Progenitors During Vertebrate Retinogenesis

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2016 May 20

PMID 27194297

Citations 9

Authors

Kangxin Jin

Mengqing Xiang

Affiliations

Soon will be listed here.

Abstract

The retina is a delicate neural tissue responsible for light signal capturing, modulating, and passing to mid-brain. The brain then translated the signals into three-dimensional vision. The mature retina is composed of more than 50 subtypes of cells, all of which are developed from a pool of early multipotent retinal progenitors, which pass through sequential statuses of oligopotent, bipotent, and unipotent progenitors, and finally become terminally differentiated retinal cells. A transitional progenitor model is proposed here to describe how intrinsic developmental programs, along with environmental cues, control the step-by-step differentiation during retinogenesis. The model could elegantly explain many current findings as well as predict roles of intrinsic factors during retinal development.

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