4D Flow MR Imaging of the Portal Venous System: a Feasibility Study in Children

Overview

Journal Eur Radiol

Specialty Radiology

Date 2016 May 20

PMID 27193778

Citations 13

Authors

Keyur Parekh

Michael Markl

Michael Rose

Susanne Schnell

Andrada Popescu

Cynthia K Rigsby

Affiliations

Soon will be listed here.

Abstract

Objectives: To determine the feasibility of 4D flow MRI for visualization and quantification of the portal venous haemodynamics in children and young adults.

Methods: 4D flow was performed in 28 paediatric patients (median age, 8.5 years; interquartile range, 5.2-16.5), 15 with non-operated native portal system and 13 with surgically created portal shunt. Image quality assessment for 3D flow visualization and flow pattern analyses was performed. Regional 4D flow peak velocity and net flow were compared with 2D-cine phase contrast MRI (2D-PC MR) in the post-surgical patients.

Results: Mean 3D flow visualization quality score was excellent (mean ± SD, 4.2 ± 0.9) with good inter-rater agreement (κ,0.67). Image quality in children aged >10 years was better than children ≤10 years (p < 0.05). Flow pattern was defined for portal, superior mesenteric, splenic veins and splenic artery in all patients. 4D flow and 2D-PC MR peak velocity and net flow were similar with good correlation (peak velocity: 4D flow 22.2 ± 9.1 cm/s and 2D-PC MR 25.2 ± 11.2 cm/s, p = 0.46; r = 0.92, p < 0.0001; net flow: 4D flow 9.5 ± 7.4 ml/s and 2D-PC MR 10.1 ± 7.3 ml/s, p = 0.65; r = 0.81, p = 0.0007).

Conclusions: 4D flow MRI is feasible and holds promise for the comprehensive 3D visualization and quantification of portal venous flow dynamics in children and young adults.

Key Points: • 4D flow MRI is feasible in children and young adults. • 4D flow MRI has the ability to non-invasively characterize portal haemodynamics. • Image quality of 4D flow MRI is better is older children. • 4D flow MRI can accurately quantify portal flow compared to 2D-cine PC MRI.

Citing Articles

Assessment of superior mesenteric vascular flow quantitation in children using four-dimensional flow magnetic resonance imaging: A feasibility study.

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Reference values for 4D flow magnetic resonance imaging of the portal venous system.

Huang A, Roberts G, Roldan-Alzate A, Wieben O, Reeder S, Oechtering T Abdom Radiol (NY). 2023; 48(6):2049-2059.

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Liver cirrhosis: relationship between fibrosis-associated hepatic morphological changes and portal hemodynamics using four-dimensional flow magnetic resonance imaging.

Higaki A, Kanki A, Yamamoto A, Ueda Y, Moriya K, Sanai H Jpn J Radiol. 2023; 41(6):625-636.

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4D Flow MRI in the portal venous system: imaging and analysis methods, and clinical applications.

Hyodo R, Takehara Y, Naganawa S Radiol Med. 2022; 127(11):1181-1198.

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Comparison of sequential CT arterioportography-arteriosplenography with standard cross-sectional imaging and endoscopy in children with portal hypertension.

Hammer S, Zeman F, Schlitt H, Stroszczynski C, Greiner B, Doppler M Sci Rep. 2022; 12(1):6554.

PMID: 35449190 PMC: 9023584. DOI: 10.1038/s41598-022-10454-y.

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