Indocyanine Green Fluorescence Navigation Thoracoscopic Metastasectomy for Pulmonary Metastasis of Hepatocellular Carcinoma

Overview

Journal Ann Thorac Cardiovasc Surg

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2016 May 20

PMID 27193496

Citations 10

Authors

Naoya Kawakita

Hiromitsu Takizawa

Kazuya Kondo

Shoji Sakiyama

Akira Tangoku

Affiliations

Soon will be listed here.

Abstract

Indocyanine green can selectively accumulate in primary hepatocellular carcinoma (HCC) and extrahepatic metastases. We report a patient who underwent resection of pulmonary metastasis of HCC using a thoracoscopic near-infrared imaging system and fluorescent navigation surgery. A 66-year-old man with suspicion of pulmonary metastasis of HCC was referred to our hospital. Indocyanine green was injected intravenously at a dose of 0.5 mg/kg body weight, 20 h before thoracoscopic surgery. An endoscopic indocyanine green near-infrared fluorescence imaging system showed clear blue fluorescence, indicating pulmonary metastasis of HCC in a lingular segment. We performed wide wedge resection using the fluorescence image for navigation to confirm the surgical margins. The specimen was histologically confirmed as a pulmonary metastasis of HCC. In conclusion, thoracoscopic indocyanine green near-infrared fluorescence imaging for pulmonary metastases of HCC is useful in identifying tumor locations and ensuring resection margins.

Citing Articles

Novel locally nebulized indocyanine green for simultaneous identification of tumor margin and intersegmental plane.

Jeon O, Kim K, Kim C, Choi B, Lee J, Kim B Int J Surg. 2024; 110(8):4708-4715.

PMID: 38752517 PMC: 11325942. DOI: 10.1097/JS9.0000000000001581.

An indocyanine green-based liquid biopsy test for circulating tumor cells for pediatric liver cancer.

Espinoza A, Kureti P, Patel R, Do S, Govindu S, Armbruster B Hepatol Commun. 2024; 8(6).

PMID: 38727682 PMC: 11093570. DOI: 10.1097/HC9.0000000000000435.

Optimization of Indocyanine Green for Intraoperative Fluorescent Image-Guided Localization of Lung Cancer; Analysis Based on Solid Component of Lung Nodule.

Jeon O, Choi B, Rho J, Kim K, Lee J, Lee J Cancers (Basel). 2023; 15(14).

PMID: 37509304 PMC: 10377801. DOI: 10.3390/cancers15143643.

Favorable control of hepatocellular carcinoma with peritoneal dissemination by surgical resection using indocyanine green fluorescence imaging: a case report and review of the literature.

Tani Y, Sato H, Yoshida R, Yasui K, Umeda Y, Yoshida K J Med Case Rep. 2022; 16(1):222.

PMID: 35659738 PMC: 9169282. DOI: 10.1186/s13256-022-03440-5.

Lung Metastases: Current Surgical Indications and New Perspectives.

Mangiameli G, Cioffi U, Alloisio M, Testori A Front Surg. 2022; 9:884915.

PMID: 35574534 PMC: 9098997. DOI: 10.3389/fsurg.2022.884915.

References

Yim A, Wan S, Lee T, Arifi A . VATS lobectomy reduces cytokine responses compared with conventional surgery. Ann Thorac Surg. 2000; 70(1):243-7. DOI: 10.1016/s0003-4975(00)01258-3. View

Kim S, Ott H, Wright C, Wain J, Morse C, Gaissert H . Pulmonary resection of metastatic sarcoma: prognostic factors associated with improved outcomes. Ann Thorac Surg. 2011; 92(5):1780-6. DOI: 10.1016/j.athoracsur.2011.05.081. View

Kim S, Lim Y, Soltesz E, De Grand A, Lee J, Nakayama A . Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol. 2003; 22(1):93-7. PMC: 2346610. DOI: 10.1038/nbt920. View

Kitai T, Inomoto T, Miwa M, Shikayama T . Fluorescence navigation with indocyanine green for detecting sentinel lymph nodes in breast cancer. Breast Cancer. 2005; 12(3):211-5. DOI: 10.2325/jbcs.12.211. View

Chen F, Sato K, Fujinaga T, Sonobe M, Shoji T, Sakai H . Pulmonary resection for metastases from hepatocellular carcinoma. World J Surg. 2008; 32(10):2213-7. DOI: 10.1007/s00268-008-9684-8. View

Kuo S, Chang Y, Huang P, Hsu H, Chen J, Lee J . Prognostic factors for pulmonary metastasectomy in hepatocellular carcinoma. Ann Surg Oncol. 2006; 14(2):992-7. PMC: 7102208. DOI: 10.1245/s10434-006-9217-3. View

Llovet J, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc J . Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008; 359(4):378-90. DOI: 10.1056/NEJMoa0708857. View

Gotoh K, Yamada T, Ishikawa O, Takahashi H, Eguchi H, Yano M . A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation. J Surg Oncol. 2009; 100(1):75-9. DOI: 10.1002/jso.21272. View

Katyal S, Oliver 3rd J, Peterson M, Ferris J, Carr B, BARON R . Extrahepatic metastases of hepatocellular carcinoma. Radiology. 2000; 216(3):698-703. DOI: 10.1148/radiology.216.3.r00se24698. View

10.

Chua T, Scolyer R, Kennedy C, Yan T, McCaughan B, Thompson J . Surgical management of melanoma lung metastasis: an analysis of survival outcomes in 292 consecutive patients. Ann Surg Oncol. 2012; 19(6):1774-81. DOI: 10.1245/s10434-011-2197-y. View

11.

Satou S, Ishizawa T, Masuda K, Kaneko J, Aoki T, Sakamoto Y . Indocyanine green fluorescent imaging for detecting extrahepatic metastasis of hepatocellular carcinoma. J Gastroenterol. 2012; 48(10):1136-43. DOI: 10.1007/s00535-012-0709-6. View

12.

Zelken J, Tufaro A . Current Trends and Emerging Future of Indocyanine Green Usage in Surgery and Oncology: An Update. Ann Surg Oncol. 2015; 22 Suppl 3:S1271-83. DOI: 10.1245/s10434-015-4743-5. View

13.

Nakajima J, Tanaka M, Matsumoto J, Takeuchi E, Fukami T, Takamoto S . Appraisal of surgical treatment for pulmonary metastasis from hepatocellular carcinoma. World J Surg. 2005; 29(6):715-8. DOI: 10.1007/s00268-005-7687-2. View

14.

Ishizawa T, Fukushima N, Shibahara J, Masuda K, Tamura S, Aoki T . Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer. 2009; 115(11):2491-504. DOI: 10.1002/cncr.24291. View

15.

Masuda M, Kuwano H, Okumura M, Amano J, Arai H, Endo S . Thoracic and cardiovascular surgery in Japan during 2012 : annual report by The Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg. 2014; 62(12):734-64. PMC: 4254159. DOI: 10.1007/s11748-014-0464-0. View