The Clinical Application of Mesenchymal Stromal Cells in Hematopoietic Stem Cell Transplantation

Overview

Journal J Hematol Oncol

Publisher Biomed Central

Specialties Hematology
Oncology

Date 2016 May 20

PMID 27193054

Citations 62

Authors

Ke Zhao

Qifa Liu

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications.

Citing Articles

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References

Liu Y, Kretz C, Maeder M, Richter C, Tsao P, Vo A . Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. Blood. 2014; 124(1):142-50. PMC: 4125349. DOI: 10.1182/blood-2014-03-561027. View

Remberger M, Ringden O . Treatment of severe acute graft-versus-host disease with mesenchymal stromal cells: a comparison with non-MSC treated patients. Int J Hematol. 2012; 96(6):822-4. DOI: 10.1007/s12185-012-1218-3. View

Arima N, Nakamura F, Fukunaga A, Hirata H, Machida H, Kouno S . Single intra-arterial injection of mesenchymal stromal cells for treatment of steroid-refractory acute graft-versus-host disease: a pilot study. Cytotherapy. 2009; 12(2):265-8. DOI: 10.3109/14653240903390795. View

Chang Y, Zhao X, Xu L, Zhang X, Wang Y, Han W . Donor-specific anti-human leukocyte antigen antibodies were associated with primary graft failure after unmanipulated haploidentical blood and marrow transplantation: a prospective study with randomly assigned training and validation sets. J Hematol Oncol. 2015; 8:84. PMC: 4496923. DOI: 10.1186/s13045-015-0182-9. View

Capelli C, Pedrini O, Valgardsdottir R, Da Roit F, Golay J, Introna M . Clinical grade expansion of MSCs. Immunol Lett. 2015; 168(2):222-7. DOI: 10.1016/j.imlet.2015.06.006. View

Kern S, Eichler H, Stoeve J, Kluter H, Bieback K . Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006; 24(5):1294-301. DOI: 10.1634/stemcells.2005-0342. View

Spaggiari G, Abdelrazik H, Becchetti F, Moretta L . MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood. 2009; 113(26):6576-83. DOI: 10.1182/blood-2009-02-203943. View

Baron F, Labopin M, Ruggeri A, Mohty M, Sanz G, Milpied N . Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the.... J Hematol Oncol. 2015; 8:107. PMC: 4594748. DOI: 10.1186/s13045-015-0207-4. View

Ferrara J, Levine J, Reddy P, Holler E . Graft-versus-host disease. Lancet. 2009; 373(9674):1550-61. PMC: 2735047. DOI: 10.1016/S0140-6736(09)60237-3. View

10.

Auletta J, Deans R, Bartholomew A . Emerging roles for multipotent, bone marrow-derived stromal cells in host defense. Blood. 2012; 119(8):1801-9. PMC: 3293637. DOI: 10.1182/blood-2011-10-384354. View

11.

Helmrich U, Marsano A, Melly L, Wolff T, Christ L, Heberer M . Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification. Tissue Eng Part C Methods. 2011; 18(4):283-92. PMC: 3311879. DOI: 10.1089/ten.TEC.2011.0413. View

12.

Peng Y, Chen X, Zhang X, Huang K, Liu L, Li H . Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10. Leukemia. 2014; 29(3):636-46. DOI: 10.1038/leu.2014.225. View

13.

Kuzmina L, Petinati N, Parovichnikova E, Lubimova L, Gribanova E, Gaponova T . Multipotent Mesenchymal Stromal Cells for the Prophylaxis of Acute Graft-versus-Host Disease-A Phase II Study. Stem Cells Int. 2012; 2012:968213. PMC: 3253492. DOI: 10.1155/2012/968213. View

14.

Haynesworth S, Goshima J, Goldberg V, Caplan A . Characterization of cells with osteogenic potential from human marrow. Bone. 1992; 13(1):81-8. DOI: 10.1016/8756-3282(92)90364-3. View

15.

Bernardo M, Ball L, Cometa A, Roelofs H, Zecca M, Avanzini M . Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation. Bone Marrow Transplant. 2010; 46(2):200-7. DOI: 10.1038/bmt.2010.87. View

16.

Zhou B, Yue R, Murphy M, Peyer J, Morrison S . Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 2014; 15(2):154-68. PMC: 4127103. DOI: 10.1016/j.stem.2014.06.008. View

17.

Haynesworth S, Baber M, Caplan A . Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992; 13(1):69-80. DOI: 10.1016/8756-3282(92)90363-2. View

18.

Seo B, Miura M, Gronthos S, Bartold P, Batouli S, Brahim J . Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004; 364(9429):149-55. DOI: 10.1016/S0140-6736(04)16627-0. View

19.

Meuleman N, Tondreau T, Ahmad I, Kwan J, Crokaert F, Delforge A . Infusion of mesenchymal stromal cells can aid hematopoietic recovery following allogeneic hematopoietic stem cell myeloablative transplant: a pilot study. Stem Cells Dev. 2009; 18(9):1247-52. DOI: 10.1089/scd.2009.0029. View

20.

Gang E, Bosnakovski D, Figueiredo C, Visser J, Perlingeiro R . SSEA-4 identifies mesenchymal stem cells from bone marrow. Blood. 2006; 109(4):1743-51. DOI: 10.1182/blood-2005-11-010504. View