Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013-2014

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2016 May 19

PMID 27191834

Citations 91

Authors

Magdalena Kendall Scott

Christina Chommanard

Xiaoyan Lu

Dianna Appelgate

LaDonna Grenz

Eileen Schneider

Susan I Gerber

Dean D Erdman

Ann Thomas

Affiliations

Soon will be listed here.

Abstract

Several human adenoviruses (HAdVs) can cause respiratory infections, some severe. HAdV-B7, which can cause severe respiratory disease, has not been recently reported in the United States but is reemerging in Asia. During October 2013-July 2014, Oregon health authorities identified 198 persons with respiratory symptoms and an HAdV-positive respiratory tract specimen. Among 136 (69%) hospitalized persons, 31% were admitted to the intensive care unit and 18% required mechanical ventilation; 5 patients died. Molecular typing of 109 specimens showed that most (59%) were HAdV-B7, followed by HAdVs-C1, -C2, -C5 (26%); HAdVs-B3, -B21 (15%); and HAdV-E4 (1%). Molecular analysis of 7 HAdV-B7 isolates identified the virus as genome type d, a strain previously identified only among strains circulating in Asia. Patients with HAdV-B7 were significantly more likely than those without HAdV-B7 to be adults and to have longer hospital stays. HAdV-B7 might be reemerging in the United States, and clinicians should consider HAdV in persons with severe respiratory infection.

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