Novel Extrapancreatic Effects of Incretin

Overview

Journal J Diabetes Investig

Specialty Endocrinology

Date 2016 May 18

PMID 27186360

Citations 12

Authors

Yuichiro Yamada

Katsushi Tsukiyama

Takehiro Sato

Tatsunori Shimizu

Hiroki Fujita

Takuma Narita

Affiliations

Soon will be listed here.

Abstract

The hormonal factors implicated as transmitters of signals from the gut to pancreatic β-cells are referred to as incretins. Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are incretins. In addition to the insulinotropic effects, we have shown, using the GIP receptor and GLP-1 receptor-deficient mice, that GIP and GLP-1 have direct actions on adipocytes and the kidney, respectively. Because GIP receptors and GLP-1 receptors are differentially expressed in a tissue-specific manner, GIP and GLP-1 have specific physiological activities, and further comprehensive characterization of the extrapancreatic actions of GIP and GLP-1 is anticipated, as dipeptidyl peptidase IV inhibitors activate both GIP and GLP-1 signaling.

Citing Articles

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