Diffuse Alveolar Hemorrhage and Recombinant Factor VIIa Treatment in Pediatric Patients

Overview

Journal Korean J Pediatr

Specialty Pediatrics

Date 2016 May 18

PMID 27186216

Citations 5

Authors

Jeong A Park

Affiliations

Soon will be listed here.

Abstract

Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or autoimmune disorders. The current treatment options, which include corticosteroids, transfusions, extracorporeal membrane oxygenation (ECMO), and immunosuppressants, have been limited and largely unsuccessful. Recombinant activated factor VII (rFVIIa) has been successfully administered, either systemically or bronchoscopically, to adults for the treatment of DAH, but there are few data on its use in pediatric patients. The current literature in the PubMed database was reviewed to evaluate the efficacy and risk of rFVIIa treatment for DAH in pediatric patients. This review discusses the diagnosis and treatment of DAH, as well as a new treatment paradigm that includes rFVIIa. Additionally, the risks and benefits of off-label use of rFVIIa in pediatric patients are discussed.

Citing Articles

Diffuse alveolar hemorrhage after hematopoietic cell transplantation- response to treatments and risk factors for mortality.

Schoettler M, Dandoy C, Harris A, Chan M, Tarquinio K, Jodele S Front Oncol. 2023; 13:1232621.

PMID: 37546403 PMC: 10399223. DOI: 10.3389/fonc.2023.1232621.

Treatment of Diffuse Alveolar Hemorrhage: Controlling Inflammation and Obtaining Rapid and Effective Hemostasis.

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Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals.

Diaz R, Almeida P, Alvarez M, Ferrer G, Hernandez F Cureus. 2020; 11(11):e6202.

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Coagulation and Bleeding Management in Pediatric Extracorporeal Membrane Oxygenation: Clinical Scenarios and Review.

Hensch L, Hui S, Teruya J Front Med (Lausanne). 2019; 5:361.

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[Diffuse alveolar hemorrhage in 4 girls].

Dai J, Chen Q, Wang L Zhongguo Dang Dai Er Ke Za Zhi. 2017; 19(10):1109-1113.

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References

Sanz M, Montesinos P . Open issues on bleeding and thrombosis in acute promyelocytic leukemia. Thromb Res. 2010; 125 Suppl 2:S51-4. DOI: 10.1016/S0049-3848(10)70013-X. View

Simpson E, Lin Y, Stanworth S, Birchall J, Doree C, Hyde C . Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Syst Rev. 2012; (3):CD005011. DOI: 10.1002/14651858.CD005011.pub4. View

Colin A, Shafieian M, Andreansky M . Bronchoscopic instillation of activated recombinant factor VII to treat diffuse alveolar hemorrhage in a child. Pediatr Pulmonol. 2010; 45(4):411. DOI: 10.1002/ppul.21178. View

Henke D, Falk R, Gabriel D . Successful treatment of diffuse alveolar hemorrhage with activated factor VII. Ann Intern Med. 2004; 140(6):493-4. DOI: 10.7326/0003-4819-140-6-200403160-00033. View

Elinoff J, Bagci U, Moriyama B, Dreiling J, Foster B, Gormley N . Recombinant human factor VIIa for alveolar hemorrhage following allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2014; 20(7):969-78. PMC: 4057942. DOI: 10.1016/j.bbmt.2014.03.015. View

Fouret P, Touboul J, Mayaud C, Akoun G, Roland J . Pulmonary Kaposi's sarcoma in patients with acquired immune deficiency syndrome: a clinicopathological study. Thorax. 1987; 42(4):262-8. PMC: 460697. DOI: 10.1136/thx.42.4.262. View

Rathi N, Tanner A, Dinh A, Dong W, Feng L, Ensor J . Low-, medium- and high-dose steroids with or without aminocaproic acid in adult hematopoietic SCT patients with diffuse alveolar hemorrhage. Bone Marrow Transplant. 2014; 50(3):420-6. DOI: 10.1038/bmt.2014.287. View

Cetin H, Yalaz M, Akisu M, Karapinar D, Kavakli K, Kultursay N . The use of recombinant activated factor VII in the treatment of massive pulmonary hemorrhage in a preterm infant. Blood Coagul Fibrinolysis. 2006; 17(3):213-6. DOI: 10.1097/01.mbc.0000220245.20036.2d. View

MacLaren R, Weber L, Brake H, Gardner M, Tanzi M . A multicenter assessment of recombinant factor VIIa off-label usage: clinical experiences and associated outcomes. Transfusion. 2005; 45(9):1434-42. DOI: 10.1111/j.1537-2995.2005.00548.x. View

10.

Newsome B, Morales J . Diffuse alveolar hemorrhage. South Med J. 2011; 104(4):269-74. DOI: 10.1097/SMJ.0b013e3182126d3b. View

11.

OConnell K, Wood J, Wise R, Lozier J, Braun M . Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006; 295(3):293-8. DOI: 10.1001/jama.295.3.293. View

12.

Kim J, Kim M, Bae E, Jeong D . Pulmonary hemorrhage in pediatric lupus anticoagulant hypoprothrombinemia syndrome. Korean J Pediatr. 2014; 57(4):202-5. PMC: 4030123. DOI: 10.3345/kjp.2014.57.4.202. View

13.

Bhat S, Yadav S, Anjan M, Dinand V, Sachdeva A . Recombinant activated factor VII usage in life threatening hemorrhage: a pediatric experience. Indian J Pediatr. 2011; 78(8):961-8. DOI: 10.1007/s12098-011-0364-6. View

14.

Collard H, Schwarz M . Diffuse alveolar hemorrhage. Clin Chest Med. 2004; 25(3):583-92, vii. DOI: 10.1016/j.ccm.2004.04.007. View

15.

Robbins R, Linder J, Stahl M, Thompson 3rd A, Haire W, Kessinger A . Diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. Am J Med. 1989; 87(5):511-8. DOI: 10.1016/s0002-9343(89)80606-0. View

16.

Dabar G, Harmouche C, Jammal M . [Efficacy of recombinant activated factor VII in diffuse alveolar haemorrhage]. Rev Mal Respir. 2011; 28(1):106-11. DOI: 10.1016/j.rmr.2010.07.007. View

17.

Travis W, Colby T, Lombard C, CARPENTER H . A clinicopathologic study of 34 cases of diffuse pulmonary hemorrhage with lung biopsy confirmation. Am J Surg Pathol. 1990; 14(12):1112-25. DOI: 10.1097/00000478-199012000-00003. View

18.

Park J, Kim B . Intrapulmonary recombinant factor VIIa for diffuse alveolar hemorrhage in children. Pediatrics. 2014; 135(1):e216-20. DOI: 10.1542/peds.2014-1782. View

19.

Harkensee C, Vasdev N, Gennery A, Willetts I, Taylor C . Prevention and management of BK-virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation--a systematic review and evidence-based guidance for clinical management. Br J Haematol. 2008; 142(5):717-31. DOI: 10.1111/j.1365-2141.2008.07254.x. View

20.

Solomonov A, Fruchter O, Zuckerman T, Brenner B, Yigla M . Pulmonary hemorrhage: A novel mode of therapy. Respir Med. 2009; 103(8):1196-200. DOI: 10.1016/j.rmed.2009.02.004. View