Indoor Allergens and Allergic Respiratory Disease

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2016 May 18

PMID 27184001

Citations 31

Authors

Anna Pomes

Martin D Chapman

Sabina Wunschmann

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The purpose of this review is to evaluate the most recent findings on indoor allergens and their impact on allergic diseases.

Recent Findings: Indoor allergens are present inside buildings (home, work environment, school), and given the chronic nature of the exposures, indoor allergies tend to be associated with the development of asthma. The most common indoor allergens are derived from dust mites, cockroaches, mammals (including wild rodents and pets), and fungi. The advent of molecular biology and proteomics has led to the identification, cloning, and expression of new indoor allergens, which have facilitated research to elucidate their role in allergic diseases. This review is an update on new allergens and their molecular features, together with the most recent reports on their avoidance for allergy prevention and their use for diagnosis and treatment. Research progress on indoor allergens will result in the development of new diagnostic tools and design of coherent strategies for immunotherapy.

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References

Fukutomi Y, Taniguchi M . Sensitization to fungal allergens: Resolved and unresolved issues. Allergol Int. 2015; 64(4):321-31. DOI: 10.1016/j.alit.2015.05.007. View

Rytkonen-Nissinen M, Saarelainen S, Randell J, Hayrinen J, Kalkkinen N, Virtanen T . IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification. Allergy Asthma Immunol Res. 2015; 7(4):384-92. PMC: 4446637. DOI: 10.4168/aair.2015.7.4.384. View

Bush R, Sanchez H, Geisler D . Molecular cloning of a major Alternaria alternata allergen, rAlt a 2. J Allergy Clin Immunol. 1999; 104(3 Pt 1):665-71. DOI: 10.1016/s0091-6749(99)70340-4. View

Jeal H, Jones M . Allergy to rodents: an update. Clin Exp Allergy. 2010; 40(11):1593-601. DOI: 10.1111/j.1365-2222.2010.03609.x. View

Almqvist C, Wickman M, Perfetti L, Berglind N, Renstrom A, Hedren M . Worsening of asthma in children allergic to cats, after indirect exposure to cat at school. Am J Respir Crit Care Med. 2001; 163(3 Pt 1):694-8. DOI: 10.1164/ajrccm.163.3.2006114. View

Nicholas C, Wegienka G, Havstad S, Zoratti E, Ownby D, Johnson C . Dog characteristics and allergen levels in the home. Ann Allergy Asthma Immunol. 2010; 105(3):228-33. PMC: 2954595. DOI: 10.1016/j.anai.2010.06.019. View

Mueller G, Edwards L, Aloor J, Fessler M, Glesner J, Pomes A . The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. J Allergy Clin Immunol. 2010; 125(4):909-917.e4. PMC: 2885876. DOI: 10.1016/j.jaci.2009.12.016. View

Konradsen J, Fujisawa T, van Hage M, Hedlin G, Hilger C, Kleine-Tebbe J . Allergy to furry animals: New insights, diagnostic approaches, and challenges. J Allergy Clin Immunol. 2014; 135(3):616-25. DOI: 10.1016/j.jaci.2014.08.026. View

Shen H, Lin W, Tam M, Wang S, Tzean S, Huang M . Characterization of allergens from Penicillium oxalicum and P. notatum by immunoblotting and N-terminal amino acid sequence analysis. Clin Exp Allergy. 1999; 29(5):642-51. DOI: 10.1046/j.1365-2222.1999.00509.x. View

10.

Chan T, Ji K, Yim A, Liu X, Zhou J, Li R . The draft genome, transcriptome, and microbiome of Dermatophagoides farinae reveal a broad spectrum of dust mite allergens. J Allergy Clin Immunol. 2014; 135(2):539-48. DOI: 10.1016/j.jaci.2014.09.031. View

11.

Simons E, Curtin-Brosnan J, Buckley T, Breysse P, Eggleston P . Indoor environmental differences between inner city and suburban homes of children with asthma. J Urban Health. 2007; 84(4):577-90. PMC: 2219555. DOI: 10.1007/s11524-007-9205-3. View

12.

Gergen P, Turkeltaub P . The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976-80 (NHANES II). J Allergy Clin Immunol. 1992; 90(4 Pt 1):579-88. DOI: 10.1016/0091-6749(92)90130-t. View

13.

Banerjee S, Weber M, Blatt K, Swoboda I, Focke-Tejkl M, Valent P . Conversion of Der p 23, a new major house dust mite allergen, into a hypoallergenic vaccine. J Immunol. 2014; 192(10):4867-75. PMC: 4582415. DOI: 10.4049/jimmunol.1400064. View

14.

Charpin C, Mata P, Charpin D, Lavaut M, Allasia C, Vervloet D . Fel d I allergen distribution in cat fur and skin. J Allergy Clin Immunol. 1991; 88(1):77-82. DOI: 10.1016/0091-6749(91)90303-6. View

15.

Sharpe R, Bearman N, Thornton C, Husk K, Osborne N . Indoor fungal diversity and asthma: a meta-analysis and systematic review of risk factors. J Allergy Clin Immunol. 2014; 135(1):110-22. DOI: 10.1016/j.jaci.2014.07.002. View

16.

Vijay H, Kurup V . Fungal allergens. Clin Allergy Immunol. 2008; 21:141-60. View

17.

De Groot H, Goei K, van Swieten P, Aalberse R . Affinity purification of a major and a minor allergen from dog extract: serologic activity of affinity-purified Can f I and of Can f I-depleted extract. J Allergy Clin Immunol. 1991; 87(6):1056-65. DOI: 10.1016/0091-6749(91)92150-y. View

18.

Custovic A, Simpson A, Pahdi H, Green R, Chapman M, Woodcock A . Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes. Thorax. 1998; 53(1):33-8. PMC: 1758692. DOI: 10.1136/thx.53.1.33. View

19.

Sedaghat A, Matsui E, Baxi S, Bollinger M, Miller R, Perzanowski M . Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma. J Allergy Clin Immunol Pract. 2015; 4(1):82-8.e1. PMC: 4715958. DOI: 10.1016/j.jaip.2015.09.006. View

20.

Chen K, Fuchs G, Sonneck K, Gieras A, Swoboda I, Douladiris N . Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering. Mol Immunol. 2008; 45(9):2486-98. DOI: 10.1016/j.molimm.2008.01.006. View