Species-specific Mutual Regulation of P53 and MiR-138 Between Human, Rat and Mouse

Overview

Journal Sci Rep

Specialty Science

Date 2016 May 18

PMID 27183959

Citations 7

Authors

Jie Li

Wei Xia

Xueting Su

Xingliang Qin

Ying Chen

Shaohua Li

Jie Dong

Hongmei Ding

Hui Li

Aixue Huang

Xingfeng Ge

Lvbin Hou

Chaonan Wang

Leqiao Sun

Chenjun Bai

Xuelian Shen

Tao Fang

Yuanlin Liu

Yi Zhang

Hongru Zhang

Hongwen Zhang

Ningsheng Shao

Affiliations

Soon will be listed here.

Abstract

In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NSCLC cells. Our results suggest the existence of species-specific differences of the regulations of miRNA against its targets and the regulations of miRNA itself by other proteins.

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