Previously Reported PDE3A-SLCO1C1 Genetic Variant Does Not Correlate with Anti-TNF Response in a Large UK Rheumatoid Arthritis Cohort

Overview

Journal Pharmacogenomics

Specialties Genetics
Pharmacology

Date 2016 May 17

PMID 27180831

Citations 7

Authors

Samantha Louise Smith

Darren Plant

Xiu Hue Lee

Jonathan Massey

Kimme Hyrich

Ann W Morgan

Anthony G Wilson

John Isaacs

Anne Barton

Affiliations

Soon will be listed here.

Abstract

Aim: A genetic variant has recently reached genome-wide significance for association with TNF-inhibitor response in rheumatoid arthritis patients. Here we undertake a replication study in a UK Caucasian population to test for association with TNF-inhibitor response.

Materials & Methods: The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Δ)DAS28 scores as outcome measures.

Results: Genotype data were available from 1750 TNF-inhibitor treated individuals. However, no evidence for association was observed (EULAR: p = 0.91 and ΔDAS28: p = 0.93). Furthermore, no significant associations were observed upon stratification by the anti-TNF received (p > 0.05).

Conclusion: In the largest replication cohort conducted to date, no evidence for association was observed.

Citing Articles

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Ferreiro-Iglesias A, Montes A, Perez-Pampin E, Canete J, Raya E, Magro-Checa C PLoS One. 2019; 14(2):e0213073.

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Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Massey J, Plant D, Hyrich K, Morgan A, Wilson A, Spiliopoulou A Pharmacogenomics J. 2018; 18(5):657-664.

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Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis.

Lopez-Rodriguez R, Perez-Pampin E, Marquez A, Blanco F, Joven B, Carreira P PLoS One. 2018; 13(5):e0196793.

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Romao V, Vital E, Fonseca J, Buch M Arthritis Res Ther. 2017; 19(1):239.

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