Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells

Overview

Journal Sci Rep

Specialty Science

Date 2016 May 14

PMID 27173446

Citations 32

Authors

Guan Wang

Liang Zhang

Xingxing Chen

Xin Xue

Qiaonan Guo

Mingyong Liu

Jianhua Zhao

Affiliations

Soon will be listed here.

Abstract

Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in the central nervous system (CNS). Here, we report that Fpr1 and Fpr2 are expressed on NSCs as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promoted NSC migration through F-actin polymerization and skewed NSC differentiation to neurons. Our study demonstrates a unique role of Fpr1 and Fpr2 in NSCs and opens a novel window for cell replacement therapies for brain and spinal cord injury.

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