Improving the Quality of Survivorship for Older Adults with Cancer

Overview

Journal Cancer

Publisher Wiley

Specialty Oncology

Date 2016 May 13

PMID 27172129

Citations 49

Authors

Supriya G Mohile

Arti Hurria

Harvey J Cohen

Julia H Rowland

Corinne R Leach

Neeraj K Arora

Beverly Canin

Hyman B Muss

Allison Magnuson

Marie Flannery

Lisa Lowenstein

Heather G Allore

Karen M Mustian

Wendy Demark-Wahnefried

Martine Extermann

Betty Ferrell

Sharon K Inouye

Stephanie A Studenski

William Dale

Affiliations

Soon will be listed here.

Abstract

In May 2015, the Cancer and Aging Research Group, in collaboration with the National Cancer Institute and the National Institute on Aging through a U13 grant, convened a conference to identify research priorities to help design and implement intervention studies to improve the quality of life and survivorship of older, frailer adults with cancer. Conference attendees included researchers with multidisciplinary expertise and advocates. It was concluded that future intervention trials for older adults with cancer should: 1) rigorously test interventions to prevent the decline of or improve health status, especially interventions focused on optimizing physical performance, nutritional status, and cognition while undergoing cancer treatment; 2) use standardized care plans based on geriatric assessment findings to guide targeted interventions; and 3) incorporate the principles of geriatrics into survivorship care plans. Also highlighted was the need to integrate the expertise of interdisciplinary team members into geriatric oncology research, improve funding mechanisms to support geriatric oncology research, and disseminate high-impact results to the research and clinical community. In conjunction with the 2 prior U13 meetings, this conference provided the framework for future research to improve the evidence base for the clinical care of older adults with cancer. Cancer 2016;122:2459-68. © 2016 American Cancer Society.

Citing Articles

Lynch Syndrome-Impact of the Type of Deficient Mismatch Repair Gene Mutation on Diagnosis, Clinical Presentation, Surveillance and Therapeutic Approaches.

Grigorie T, Potlog G, Alexandrescu S Medicina (Kaunas). 2025; 61(1).

PMID: 39859102 PMC: 11766940. DOI: 10.3390/medicina61010120.

Preferences for breast cancer survivorship programs among multiracial and ethnic women.

Anderson L, Bhattacharyya O, Clark A, Smith S, Grimm M, Fox E Res Sq. 2024; .

PMID: 39711548 PMC: 11661299. DOI: 10.21203/rs.3.rs-5312826/v1.

Interdisciplinary provider visits attenuate relationship between patient concerns and distress in older adults with cancer.

McConnell K, Zaleta A, Saracino R, Miller M Qual Life Res. 2024; 33(11):2975-2985.

PMID: 39162969 DOI: 10.1007/s11136-024-03760-7.

Feasibility of an exercise-nutrition-psychology integrated rehabilitation model based on mobile health and virtual reality for cancer patients: a single-center, single-arm, prospective phase II study.

Qi Y, Wang M, Xue Y, Yue J, Qi C, Shang W BMC Palliat Care. 2024; 23(1):155.

PMID: 38902684 PMC: 11191250. DOI: 10.1186/s12904-024-01487-3.

Clinical trials in older patients with cancer - typical challenges, possible solutions, and a paradigm of study design in breast cancer.

Karihtala P, Schiza A, Fountzilas E, Geisler J, Meattini I, Risi E Acta Oncol. 2024; 63:441-447.

PMID: 38881342 PMC: 11332548. DOI: 10.2340/1651-226X.2023.40365.

References

Mohile S, Velarde C, Hurria A, Magnuson A, Lowenstein L, Pandya C . Geriatric Assessment-Guided Care Processes for Older Adults: A Delphi Consensus of Geriatric Oncology Experts. J Natl Compr Canc Netw. 2015; 13(9):1120-30. PMC: 4630807. DOI: 10.6004/jnccn.2015.0137. View

Baitar A, Kenis C, Moor R, Decoster L, Luce S, Bron D . Implementation of geriatric assessment-based recommendations in older patients with cancer: A multicentre prospective study. J Geriatr Oncol. 2015; 6(5):401-10. DOI: 10.1016/j.jgo.2015.07.005. View

Hurria A, Togawa K, Mohile S, Owusu C, Klepin H, Gross C . Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011; 29(25):3457-65. PMC: 3624700. DOI: 10.1200/JCO.2011.34.7625. View

Hurria A, Levit L, Dale W, Mohile S, Muss H, Fehrenbacher L . Improving the Evidence Base for Treating Older Adults With Cancer: American Society of Clinical Oncology Statement. J Clin Oncol. 2015; 33(32):3826-33. DOI: 10.1200/JCO.2015.63.0319. View

Nightingale G, Hajjar E, Swartz K, Andrel-Sendecki J, Chapman A . Evaluation of a pharmacist-led medication assessment used to identify prevalence of and associations with polypharmacy and potentially inappropriate medication use among ambulatory senior adults with cancer. J Clin Oncol. 2015; 33(13):1453-9. DOI: 10.1200/JCO.2014.58.7550. View

Hayman J, Langa K, Kabeto M, Katz S, DeMonner S, Chernew M . Estimating the cost of informal caregiving for elderly patients with cancer. J Clin Oncol. 2001; 19(13):3219-25. DOI: 10.1200/JCO.2001.19.13.3219. View

Seymour M, Thompson L, Wasan H, Middleton G, Brewster A, Shepherd S . Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. Lancet. 2011; 377(9779):1749-59. PMC: 3109515. DOI: 10.1016/S0140-6736(11)60399-1. View

Mohile S, Xian Y, Dale W, Fisher S, Rodin M, Morrow G . Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries. J Natl Cancer Inst. 2009; 101(17):1206-15. PMC: 3937788. DOI: 10.1093/jnci/djp239. View

Inouye S, Bogardus Jr S, Charpentier P, Leo-Summers L, Acampora D, Holford T . A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. 1999; 340(9):669-76. DOI: 10.1056/NEJM199903043400901. View

10.

Ellis G, Whitehead M, ONeill D, Langhorne P, Robinson D . Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database Syst Rev. 2011; (7):CD006211. PMC: 4164377. DOI: 10.1002/14651858.CD006211.pub2. View

11.

Hubbard R, OMahony M, Savva G, Calver B, Woodhouse K . Inflammation and frailty measures in older people. J Cell Mol Med. 2009; 13(9B):3103-9. PMC: 4516469. DOI: 10.1111/j.1582-4934.2009.00733.x. View

12.

Antoun S, Birdsell L, Sawyer M, Venner P, Escudier B, Baracos V . Association of skeletal muscle wasting with treatment with sorafenib in patients with advanced renal cell carcinoma: results from a placebo-controlled study. J Clin Oncol. 2010; 28(6):1054-60. DOI: 10.1200/JCO.2009.24.9730. View

13.

Caillet P, Canoui-Poitrine F, Vouriot J, Berle M, Reinald N, Krypciak S . Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer: ELCAPA study. J Clin Oncol. 2011; 29(27):3636-42. DOI: 10.1200/JCO.2010.31.0664. View

14.

Dale W, Mohile S, Eldadah B, Trimble E, Schilsky R, Cohen H . Biological, clinical, and psychosocial correlates at the interface of cancer and aging research. J Natl Cancer Inst. 2012; 104(8):581-9. PMC: 3328422. DOI: 10.1093/jnci/djs145. View

15.

Faul L, Luta G, Sheppard V, Isaacs C, Cohen H, Muss H . Associations among survivorship care plans, experiences of survivorship care, and functioning in older breast cancer survivors: CALGB/Alliance 369901. J Cancer Surviv. 2014; 8(4):627-37. PMC: 4386650. DOI: 10.1007/s11764-014-0371-5. View

16.

Parry C, Kent E, Mariotto A, Alfano C, Rowland J . Cancer survivors: a booming population. Cancer Epidemiol Biomarkers Prev. 2011; 20(10):1996-2005. PMC: 3422885. DOI: 10.1158/1055-9965.EPI-11-0729. View

17.

Haley W . Family caregivers of elderly patients with cancer: understanding and minimizing the burden of care. J Support Oncol. 2004; 1(4 Suppl 2):25-9. View

18.

Palumbo A, Bringhen S, Mateos M, Larocca A, Facon T, Kumar S . Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report. Blood. 2015; 125(13):2068-74. PMC: 4375104. DOI: 10.1182/blood-2014-12-615187. View

19.

Hubbard J, Cohen H, Muss H . Incorporating biomarkers into cancer and aging research. J Clin Oncol. 2014; 32(24):2611-6. PMC: 4876339. DOI: 10.1200/JCO.2014.55.4261. View

20.

Jung H, Kim J, Kim J, Kim S, Yang H, Lee J . Effect of muscle mass on toxicity and survival in patients with colon cancer undergoing adjuvant chemotherapy. Support Care Cancer. 2014; 23(3):687-94. DOI: 10.1007/s00520-014-2418-6. View