Management of Conjunctival Melanoma: Critical Assessment of Sentinel Lymph Node Biopsy

Overview

Journal Ocul Oncol Pathol

Date 2016 May 13

PMID 27171676

Citations 4

Authors

Hassan A Aziz

Brian R Gastman

Arun D Singh

Affiliations

Soon will be listed here.

Abstract

Conjunctival melanoma (CoM) is a rare and aggressive form of melanoma. There is a lack of consensus on a unified management plan for this disease. Recently, a few centers have adopted the regional sentinel lymph node biopsy into the staging process of CoM. This study presents a critical assessment of the role of sentinel lymph node biopsy in CoM and presents a simplified management algorithm based on high-risk clinical and pathological features.

Citing Articles

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References

Maalouf T, Dolivet G, Angioi K, Leroux A, Genin P, George J . Sentinel lymph node biopsy in patients with conjunctival and eyelid cancers: experience in 17 patients. Ophthalmic Plast Reconstr Surg. 2012; 28(1):30-4. DOI: 10.1097/IOP.0b013e31822fb44b. View

Lommatzsch P, Werschnik C . [Malignant conjunctival melanoma. Clinical review with recommendations for diagnosis, therapy and follow-up]. Klin Monbl Augenheilkd. 2002; 219(10):710-21. DOI: 10.1055/s-2002-35693. View

Werschnik C, Lommatzsch P . Long-term follow-up of patients with conjunctival melanoma. Am J Clin Oncol. 2002; 25(3):248-55. DOI: 10.1097/00000421-200206000-00009. View

Vajdic C, Kricker A, Giblin M, McKenzie J, Aitken J, Giles G . Incidence of ocular melanoma in Australia from 1990 to 1998. Int J Cancer. 2003; 105(1):117-22. DOI: 10.1002/ijc.11057. View

Yu G, Hu D, McCormick S, Finger P . Conjunctival melanoma: is it increasing in the United States?. Am J Ophthalmol. 2003; 135(6):800-6. DOI: 10.1016/s0002-9394(02)02288-2. View

Yousef Y, Finger P . Predictive value of the seventh edition American Joint Committee on Cancer staging system for conjunctival melanoma. Arch Ophthalmol. 2012; 130(5):599-606. DOI: 10.1001/archophthalmol.2011.2566. View

Kurli M, Finger P . Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience. Graefes Arch Clin Exp Ophthalmol. 2005; 243(11):1108-14. DOI: 10.1007/s00417-004-1080-y. View

Wilson M, Fleming J, Fleming R, Haik B . Sentinel node biopsy for orbital and ocular adnexal tumors. Ophthalmic Plast Reconstr Surg. 2001; 17(5):338-44; discussion 344-5. DOI: 10.1097/00002341-200109000-00008. View

Missotten G, Keijser S, de Keizer R, de Wolff-Rouendaal D . Conjunctival melanoma in the Netherlands: a nationwide study. Invest Ophthalmol Vis Sci. 2004; 46(1):75-82. DOI: 10.1167/iovs.04-0344. View

10.

Esmaeli B, Roberts D, Ross M, Fellman M, Cruz H, Kim S . Histologic features of conjunctival melanoma predictive of metastasis and death (an American Ophthalmological thesis). Trans Am Ophthalmol Soc. 2013; 110:64-73. PMC: 3671367. View

11.

Shields C, Kaliki S, Al-Dahmash S, Lally S, Shields J . American Joint Committee on Cancer (AJCC) clinical classification predicts conjunctival melanoma outcomes. Ophthalmic Plast Reconstr Surg. 2012; 28(5):313-23. DOI: 10.1097/IOP.0b013e3182611670. View

12.

Lim M, Tatla T, Hersh D, Hungerford J . Patterns of regional head and neck lymph node metastasis in primary conjunctival malignant melanoma. Br J Ophthalmol. 2006; 90(12):1468-71. PMC: 1857530. DOI: 10.1136/bjo.2006.099754. View

13.

Shields C, Markowitz J, Belinsky I, Schwartzstein H, George N, Lally S . Conjunctival melanoma: outcomes based on tumor origin in 382 consecutive cases. Ophthalmology. 2010; 118(2):389-95.e1-2. DOI: 10.1016/j.ophtha.2010.06.021. View

14.

Tuomaala S, Eskelin S, Tarkkanen A, Kivela T . Population-based assessment of clinical characteristics predicting outcome of conjunctival melanoma in whites. Invest Ophthalmol Vis Sci. 2002; 43(11):3399-408. View

15.

Tanabe K, Reintgen D . The role of sentinel lymph node mapping for melanoma. Adv Surg. 1997; 31:79-103. View

16.

Morton D, Wanek L, Nizze J, Elashoff R, Wong J . Improved long-term survival after lymphadenectomy of melanoma metastatic to regional nodes. Analysis of prognostic factors in 1134 patients from the John Wayne Cancer Clinic. Ann Surg. 1991; 214(4):491-9; discussion 499-501. PMC: 1358554. DOI: 10.1097/00000658-199110000-00013. View

17.

Esmaeli B, Eicher S, Popp J, Delpassand E, Prieto V, Gershenwald J . Sentinel lymph node biopsy for conjunctival melanoma. Ophthalmic Plast Reconstr Surg. 2002; 17(6):436-42. DOI: 10.1097/00002341-200111000-00010. View

18.

Karim R, Conway R . Conservative resection and adjuvant plaque brachytherapy for early-stage conjunctival melanoma. Clin Exp Ophthalmol. 2010; 39(4):293-8. DOI: 10.1111/j.1442-9071.2010.02469.x. View

19.

Isager P, Engholm G, Overgaard J, Storm H . Uveal and conjunctival malignant melanoma in denmark 1943-97: observed and relative survival of patients followed through 2002. Ophthalmic Epidemiol. 2006; 13(2):85-96. DOI: 10.1080/09286580600553330. View

20.

Savar A, Esmaeli B, Ho H, Liu S, Prieto V . Conjunctival melanoma: local-regional control rates, and impact of high-risk histopathologic features. J Cutan Pathol. 2010; 38(1):18-24. DOI: 10.1111/j.1600-0560.2010.01625.x. View