Double Primary Malignant Fibrous Histiocytoma and Squamous Cell Carcinoma of the Larynx Treated with Laser Laryngeal Conservation Surgery

Overview

Journal Ecancermedicalscience

Specialty Oncology

Date 2016 May 13

PMID 27170836

Citations 4

Authors

P D Karkos

S Dova

S Sotiriou

K Markou

I Kostopoulos

Affiliations

Soon will be listed here.

Abstract

Βackground: Synchronous multiple malignancies of the larynx are rare. We present a case here of synchronous primary laryngeal squamous cell carcinoma (SCC) and malignant fibrous histiocytoma (MFH) in a patient with hoarseness though with no history of exposure to radiation. Clinical, intraoperative, and histopathological findings in this patient are discussed.

Methods: Wide laser excision of the left supraglottic lesion and laser cordectomy of the right true vocal cord were performed.

Results: The patient presented with a recurrence of the ΜFH alone (with no recurrence of the SCC) two months after the first operation and was managed with an extended second look laser cordectomy. The patient is under regular follow-up and remained disease-free nine months from diagnosis.

Conclusions: Our results show that early-stage simultaneous tumours of the larynx and particularly MFH and SCC can be treated efficiently with endoscopic laryngeal surgery alone. Close follow-up is of paramount importance because of the aggressive nature of MFH.

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References

Nakanishi S, Shinomiya S, Sano T, Hizawa K . Immunohistochemical observation of intracytoplasmic lysozyme in proliferative and neoplastic fibrohistiocytic lesions. Acta Pathol Jpn. 1982; 32(6):949-59. DOI: 10.1111/j.1440-1827.1982.tb02077.x. View

Roy S, Purgina B, Seethala R . Spindle cell carcinoma of the larynx with rhabdomyoblastic heterologous element: a rare form of divergent differentiation. Head Neck Pathol. 2012; 7(3):263-7. PMC: 3738762. DOI: 10.1007/s12105-012-0402-3. View

Hartel P, Jackson J, Ducatman B, Zhang P . CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker. J Cutan Pathol. 2006; 33 Suppl 2:24-8. DOI: 10.1111/j.1600-0560.2006.00492.x. View

Grogg K, Macon W, Kurtin P, Nascimento A . A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. Mod Pathol. 2004; 18(2):260-6. DOI: 10.1038/modpathol.3800294. View

Bishop J, Montgomery E, Westra W . Use of p40 and p63 immunohistochemistry and human papillomavirus testing as ancillary tools for the recognition of head and neck sarcomatoid carcinoma and its distinction from benign and malignant mesenchymal processes. Am J Surg Pathol. 2014; 38(2):257-64. PMC: 4313886. DOI: 10.1097/PAS.0000000000000119. View

Deniz K, Coban G, Okten T . Anti-CD10 (56C6) expression in soft tissue sarcomas. Pathol Res Pract. 2012; 208(5):281-5. DOI: 10.1016/j.prp.2012.02.002. View

Cao X, Liu J, Zheng Y, Li Q, Teng Y, Li Y . Simultaneous squamous cell carcinoma with primary malignant fibrous histiocytoma of the larynx: a case report. Mol Med Rep. 2012; 5(4):971-3. PMC: 3493047. DOI: 10.3892/mmr.2012.775. View

Wieland C, Dyck R, Weenig R, Comfere N . The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. J Cutan Pathol. 2011; 38(11):884-8. DOI: 10.1111/j.1600-0560.2011.01768.x. View

Kanner W, Brill 2nd L, Patterson J, Wick M . CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. J Cutan Pathol. 2010; 37(7):744-50. DOI: 10.1111/j.1600-0560.2010.01534.x. View

10.

Rosenberg A, OConnell J, Dickersin G, Bhan A . Expression of epithelial markers in malignant fibrous histiocytoma of the musculoskeletal system: an immunohistochemical and electron microscopic study. Hum Pathol. 1993; 24(3):284-93. DOI: 10.1016/0046-8177(93)90039-j. View

11.

Ortiz Bish F, Ruiz Clemente J, Galera Ruiz H, De Mingo Fernandez E, Munoz Borge F . [Malignant laryngeal fibrous histiocytoma (MLFH). Report of two unusual cases]. Acta Otorrinolaringol Esp. 2004; 55(8):390-4. DOI: 10.1016/s0001-6519(04)78541-6. View

12.

Ribeiro R, Fonteles M, Zucoloto S, Bacchi C . Immunohistochemical identification of lysozyme and vimentin in an experimental malignant fibrous histiocytoma. Braz J Med Biol Res. 1988; 21(5):995-7. View

13.

Barak S, Wang Z, Miettinen M . Immunoreactivity for calretinin and keratins in desmoid fibromatosis and other myofibroblastic tumors: a diagnostic pitfall. Am J Surg Pathol. 2012; 36(9):1404-9. PMC: 7477945. DOI: 10.1097/PAS.0b013e3182556def. View

14.

Anghelina F, Ionita E, Chiutu L, Mogoanta C, Ciolofan S, Iosif C . Malignant fibrous histiocytoma of larynx with giant cell: case report and histological-clinical considerations. Rom J Morphol Embryol. 2009; 50(3):481-5. View

15.

Barnes L, Kanbour A . Malignant fibrous histiocytoma of the head and neck. A report of 12 cases. Arch Otolaryngol Head Neck Surg. 1988; 114(10):1149-56. DOI: 10.1001/archotol.1988.01860220083030. View

16.

Miettinen M, Soini Y . Malignant fibrous histiocytoma. Heterogeneous patterns of intermediate filament proteins by immunohistochemistry. Arch Pathol Lab Med. 1989; 113(12):1363-6. View

17.

Murakami I, Itami S, Fujiwara S, Terashi H, Kurata S, Honda T . Recurrent malignant fibrous histiocytoma with expression of cytokeratin. J Dermatol. 1991; 18(6):340-4. DOI: 10.1111/j.1346-8138.1991.tb03095.x. View

18.

Ferlito A . Histiocytic tumors of the larynx: a clinicopathological study with review of the literature. Cancer. 1978; 42(2):611-22. DOI: 10.1002/1097-0142(197808)42:2<611::aid-cncr2820420230>3.0.co;2-0. View

19.

Guney E, Yigitbasi O, Balkanli S, Canoz O . Postirradiation malignant fibrous histiocytoma of the larynx: a case report. Am J Otolaryngol. 2002; 23(5):293-6. DOI: 10.1053/ajot.2002.124554. View

20.

Takata T, Ito H, Ogawa I, Miyauchi M, Ijuhin N, Nikai H . Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. Virchows Arch A Pathol Anat Histopathol. 1991; 419(3):177-82. DOI: 10.1007/BF01626345. View