Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases

Overview

Journal J Exp Neurosci

Publisher Sage Publications

Specialty Neurology

Date 2016 May 12

PMID 27168725

Citations 25

Authors

Ana Maria Olivares

Oscar Andres Moreno-Ramos

Neena B Haider

Affiliations

Soon will be listed here.

Abstract

The nuclear hormone receptor (NHR) superfamily is composed of a wide range of receptors involved in a myriad of important biological processes, including development, growth, metabolism, and maintenance. Regulation of such wide variety of functions requires a complex system of gene regulation that includes interaction with transcription factors, chromatin-modifying complex, and the proper recognition of ligands. NHRs are able to coordinate the expression of genes in numerous pathways simultaneously. This review focuses on the role of nuclear receptors in the central nervous system and, in particular, their role in regulating the proper development and function of the brain and the eye. In addition, the review highlights the impact of mutations in NHRs on a spectrum of human diseases from autism to retinal degeneration.

Citing Articles

Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration.

Yang X, Huang Y Int J Mol Sci. 2025; 26(5).

PMID: 40076922 PMC: 11900312. DOI: 10.3390/ijms26052304.

Exploring Toxicity of Per- and Polyfluoroalkyl Substances (PFAS) Mixture Through ADMET and Toxicogenomic In Silico Analysis: Molecular Insights.

Baralic K, Petkovski T, Piletic N, Maric D, Djordjevic A, Antonijevic B Int J Mol Sci. 2024; 25(22).

PMID: 39596398 PMC: 11594668. DOI: 10.3390/ijms252212333.

The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors.

Teichmann T, Pfluger-Muller B, Gimenez V, Sailer F, Dirks H, Zehr S Br J Pharmacol. 2024; 182(5):1164-1182.

PMID: 39563075 PMC: 11790392. DOI: 10.1111/bph.17366.

New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer's disease.

Cao Y, Zhao L, Chen Z, Li S Front Neurosci. 2024; 18:1430465.

PMID: 39323915 PMC: 11422391. DOI: 10.3389/fnins.2024.1430465.

ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibiting to suppress tau phosphorylation.

Sato K, Takayama K, Saito Y, Inoue S Proc Natl Acad Sci U S A. 2024; 121(37):e2406854121.

PMID: 39231208 PMC: 11406303. DOI: 10.1073/pnas.2406854121.

References

Sumi Y, Yagita K, Yamaguchi S, Ishida Y, Kuroda Y, Okamura H . Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus. Neurosci Lett. 2002; 320(1-2):13-6. DOI: 10.1016/s0304-3940(02)00011-3. View

Qi C, Surapureddi S, Zhu Y, Yu S, Kashireddy P, Rao M . Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis. J Biol Chem. 2003; 278(28):25281-4. DOI: 10.1074/jbc.C300175200. View

Landis D, Reese T . Structure of the Purkinje cell membrane in staggerer and weaver mutant mice. J Comp Neurol. 1977; 171(2):247-60. DOI: 10.1002/cne.901710208. View

Wang Q, Anzick S, Richter W, Meltzer P, Simons Jr S . Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors. J Steroid Biochem Mol Biol. 2004; 91(4-5):197-210. DOI: 10.1016/j.jsbmb.2004.04.007. View

Messer A, Eisenberg B . Staggerer mutant mouse Purkinje cells do not contain detectable calmodulin mRNA. J Neurochem. 1990; 55(1):293-302. DOI: 10.1111/j.1471-4159.1990.tb08851.x. View

Wansa K, Harris J, Yan G, Ordentlich P, Muscat G . The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003; 278(27):24776-90. DOI: 10.1074/jbc.M300088200. View

Desvergne B, Wahli W . Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999; 20(5):649-88. DOI: 10.1210/edrv.20.5.0380. View

Okamoto K, Isohashi F . Macromolecular translocation inhibitor II (Zn(2+)-binding protein, parathymosin) interacts with the glucocorticoid receptor and enhances transcription in vivo. J Biol Chem. 2005; 280(44):36986-93. DOI: 10.1074/jbc.M506056200. View

Laflamme C, Filion C, Bridge J, Ladanyi M, Goldring M, Labelle Y . The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. Cancer Res. 2003; 63(2):449-54. View

10.

Jetten A, Joo J . Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development. Adv Dev Biol. 2008; 16:313-355. PMC: 2312092. DOI: 10.1016/S1574-3349(06)16010-X. View

11.

Laudet V . Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor. J Mol Endocrinol. 1998; 19(3):207-26. DOI: 10.1677/jme.0.0190207. View

12.

Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T . DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci. 2005; 8(7):873-80. DOI: 10.1038/nn1492. View

13.

Jia L, Oh E, Ng L, Srinivas M, Brooks M, Swaroop A . Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 2009; 106(41):17534-9. PMC: 2765160. DOI: 10.1073/pnas.0902425106. View

14.

Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G . International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev. 2006; 58(4):798-836. DOI: 10.1124/pr.58.4.10. View

15.

Chan S, Kachilele S, McCabe C, Tannahill L, Boelaert K, Gittoes N . Early expression of thyroid hormone deiodinases and receptors in human fetal cerebral cortex. Brain Res Dev Brain Res. 2002; 138(2):109-16. DOI: 10.1016/s0165-3806(02)00459-5. View

16.

Vega R, Huss J, Kelly D . The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol. 2000; 20(5):1868-76. PMC: 85369. DOI: 10.1128/MCB.20.5.1868-1876.2000. View

17.

Giangrande P, Kimbrel E, Edwards D, McDonnell D . The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol. 2000; 20(9):3102-15. PMC: 85605. DOI: 10.1128/MCB.20.9.3102-3115.2000. View

18.

Yan Z, Jetten A . Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor. J Biol Chem. 2000; 275(45):35077-85. DOI: 10.1074/jbc.M005566200. View

19.

Suetsugi M, Su L, Karlsberg K, Yuan Y, Chen S . Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003; 1(13):981-91. View

20.

Goldowitz D, Hamre K . The cells and molecules that make a cerebellum. Trends Neurosci. 1998; 21(9):375-82. DOI: 10.1016/s0166-2236(98)01313-7. View