Antibodies to Hepatitis B Virus Surface Antigen and Survival of Hemodialysis Patients - a Prospective Study

Overview

Journal Expert Rev Vaccines

Date 2016 May 12

PMID 27166852

Citations 5

Authors

Alicja E Grzegorzewska

Monika K Swiderska

Wojciech Warchol

Affiliations

Soon will be listed here.

Abstract

Background: Antibodies to hepatitis B virus (HBV) surface antigen (anti-HBs) may develop in response to HBV vaccination or infection. We investigated whether anti-HBs are an independent predictor of survival in hemodialysis (HD) patients.

Methods: A 6-year prospective study was conducted in 532 HD patients. Survival analyses were performed using the Kaplan-Meier method and the Cox proportional hazard model.

Results: In HBV non-infected patients, age (P = 0.005), coronary artery disease (P = 0.002), and non-response to HBV vaccine (P = 0.008) were the independent risk factors of all-cause mortality. In HBV infected patients, the only independent predictor of all-cause mortality was coronary artery disease (P = 0.002).

Conclusion: The ability to produce the protective anti-HBs titer in response to HBV vaccine is a positive predictor of survival in HBV non-infected HD patients.

Citing Articles

Comparison of seroconversion rates after hepatitis B vaccination in patients with advanced chronic kidney disease and those receiving maintenance hemodialysis.

Fujikura T, Isobe S, Oikawa S, Ishigaki S, Katahashi N, Iwakura T Clin Exp Nephrol. 2025; .

PMID: 40035977 DOI: 10.1007/s10157-025-02648-1.

Hepatitis B virus vaccine immune response and mortality in dialysis patients: a meta-analysis.

Udomkarnjananun S, Takkavatakarn K, Praditpornsilpa K, Nader C, Eiam-Ong S, Jaber B J Nephrol. 2019; 33(2):343-354.

PMID: 31701375 DOI: 10.1007/s40620-019-00668-1.

ENHO, RXRA, and LXRA polymorphisms and dyslipidaemia, related comorbidities and survival in haemodialysis patients.

Grzegorzewska A, Niepolski L, Swiderska M, Mostowska A, Stolarek I, Warchol W BMC Med Genet. 2018; 19(1):194.

PMID: 30413149 PMC: 6234788. DOI: 10.1186/s12881-018-0708-4.

Circulating Interferon-3, Responsiveness to HBV Vaccination, and HBV/HCV Infections in Haemodialysis Patients.

Grzegorzewska A, Swiderska M, Mostowska A, Jagodzinski P Biomed Res Int. 2017; 2017:3713025.

PMID: 29226133 PMC: 5684519. DOI: 10.1155/2017/3713025.

Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients - a prospective study.

Grzegorzewska A, Swiderska M, Mostowska A, Warchol W, Jagodzinski P BMC Nephrol. 2017; 18(1):165.

PMID: 28525983 PMC: 5437603. DOI: 10.1186/s12882-017-0582-x.