Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate

Overview

Journal ACS Cent Sci

Specialty Chemistry

Date 2016 May 11

PMID 27163023

Citations 15

Authors

Matthew T Villaume

Eran Sella

Garrett Saul

Robert M Borzilleri

Joseph Fargnoli

Kathy A Johnston

Haiying Zhang

Mark P Fereshteh

T G Murali Dhar

Phil S Baran

Affiliations

Soon will be listed here.

Abstract

The fungal-derived Taiwanese natural product antroquinonol A has attracted both academic and commercial interest due to its reported exciting biological properties. This reduced quinone is currently in phase II trials (USA and Taiwan) for the treatment of non-small-cell lung carcinoma (NSCLC) and was recently granted orphan drug status by the FDA for the treatment of pancreatic cancer and acute myeloid leukemia. Pending successful completion of human clinical trials, antroquinonol is expected to be commercialized under the trade name Hocena. A synthesis-enabled biological re-examination of this promising natural product, however, reveals minimal in vitro and in vivo antitumor activity in preclinical models.

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