Transposable Elements in the Mammalian Embryo: Pioneers Surviving Through Stealth and Service

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2016 May 11

PMID 27161170

Citations 86

Authors

Patricia Gerdes

Sandra R Richardson

Dixie L Mager

Geoffrey J Faulkner

Affiliations

Soon will be listed here.

Abstract

Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome.

Citing Articles

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Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts.

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Technology to the rescue: how to uncover the role of transposable elements in preimplantation development.

Deaville L, Berrens R Biochem Soc Trans. 2024; 52(3):1349-1362.

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Characteristics and expression of lncRNA and transposable elements in aneuploidy.

Zhang S, Wang R, Zhu X, Zhang L, Liu X, Sun L iScience. 2023; 26(12):108494.

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