Isolating the Effects of Surface Vasculature in Infant Neuroimaging Using Short-distance Optical Channels: a Combination of Local and Global Effects

Overview

Journal Neurophotonics

Date 2016 May 10

PMID 27158631

Citations 13

Authors

Lauren L Emberson

Stephen L Crosswhite

James R Goodwin

Andrew J Berger

Richard N Aslin

Affiliations

Soon will be listed here.

Abstract

Functional near-infrared spectroscopy (fNIRS) records hemodynamic changes in the cortex arising from neurovascular coupling. However, (noninvasive) fNIRS recordings also record surface vascular signals arising from noncortical sources (e.g., in the skull, skin, dura, and other tissues located between the sensors and the brain). A current and important focus in the fNIRS community is determining how to remove these noncortical vascular signals to reduce noise and to prevent researchers from erroneously attributing responses to cortical sources. The current study is the first to test a popular method for removing signals from the surface vasculature (removing short, 1 cm, channel recordings from long, 3 cm, channel recordings) in human infants, a population frequently studied using fNIRS. We find evidence that this method does remove surface vasculature signals and indicates the presence of both local and global surface vasculature signals. However, we do not find that the removal of this information changes the statistical inferences drawn from the data. This latter result not only questions the importance of removing surface vasculature responses for empiricists employing this method, but also calls for future research using other tasks (e.g., ones with a weaker initial result) with this population and possibly additional methods for removing signals arising from the surface vasculature in infants.

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References

Taga G, Asakawa K, Maki A, Konishi Y, Koizumi H . Brain imaging in awake infants by near-infrared optical topography. Proc Natl Acad Sci U S A. 2003; 100(19):10722-7. PMC: 196871. DOI: 10.1073/pnas.1932552100. View

Taga G, Asakawa K, Hirasawa K, Konishi Y . Hemodynamic responses to visual stimulation in occipital and frontal cortex of newborn infants: a near-infrared optical topography study. Early Hum Dev. 2003; 75 Suppl:S203-10. DOI: 10.1016/j.earlhumdev.2003.08.023. View

Aslin R, Mehler J . Near-infrared spectroscopy for functional studies of brain activity in human infants: promise, prospects, and challenges. J Biomed Opt. 2005; 10(1):11009. DOI: 10.1117/1.1854672. View

Saager R, Berger A . Direct characterization and removal of interfering absorption trends in two-layer turbid media. J Opt Soc Am A Opt Image Sci Vis. 2005; 22(9):1874-82. DOI: 10.1364/josaa.22.001874. View

Grill-Spector K, Henson R, Martin A . Repetition and the brain: neural models of stimulus-specific effects. Trends Cogn Sci. 2005; 10(1):14-23. DOI: 10.1016/j.tics.2005.11.006. View

Plichta M, Heinzel S, Ehlis A, Pauli P, Fallgatter A . Model-based analysis of rapid event-related functional near-infrared spectroscopy (NIRS) data: a parametric validation study. Neuroimage. 2007; 35(2):625-34. DOI: 10.1016/j.neuroimage.2006.11.028. View

Taga G, Asakawa K . Selectivity and localization of cortical response to auditory and visual stimulation in awake infants aged 2 to 4 months. Neuroimage. 2007; 36(4):1246-52. DOI: 10.1016/j.neuroimage.2007.04.037. View

Zhang Q, Brown E, Strangman G . Adaptive filtering for global interference cancellation and real-time recovery of evoked brain activity: a Monte Carlo simulation study. J Biomed Opt. 2007; 12(4):044014. DOI: 10.1117/1.2754714. View

Taga G, Homae F, Watanabe H . Effects of source-detector distance of near infrared spectroscopy on the measurement of the cortical hemodynamic response in infants. Neuroimage. 2007; 38(3):452-60. DOI: 10.1016/j.neuroimage.2007.07.050. View

10.

Minagawa-Kawai Y, Mori K, Hebden J, Dupoux E . Optical imaging of infants' neurocognitive development: recent advances and perspectives. Dev Neurobiol. 2008; 68(6):712-28. DOI: 10.1002/dneu.20618. View

11.

Wilcox T, Bortfeld H, Woods R, Wruck E, Boas D . Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration. Dev Sci. 2008; 11(3):361-70. PMC: 2584206. DOI: 10.1111/j.1467-7687.2008.00681.x. View

12.

Saager R, Berger A . Measurement of layer-like hemodynamic trends in scalp and cortex: implications for physiological baseline suppression in functional near-infrared spectroscopy. J Biomed Opt. 2008; 13(3):034017. DOI: 10.1117/1.2940587. View

13.

Watanabe H, Homae F, Nakano T, Taga G . Functional activation in diverse regions of the developing brain of human infants. Neuroimage. 2008; 43(2):346-57. DOI: 10.1016/j.neuroimage.2008.07.014. View

14.

Gervain J, Macagno F, Cogoi S, Pena M, Mehler J . The neonate brain detects speech structure. Proc Natl Acad Sci U S A. 2008; 105(37):14222-7. PMC: 2544605. DOI: 10.1073/pnas.0806530105. View

15.

Zhang Q, Strangman G, Ganis G . Adaptive filtering to reduce global interference in non-invasive NIRS measures of brain activation: how well and when does it work?. Neuroimage. 2009; 45(3):788-94. PMC: 2671198. DOI: 10.1016/j.neuroimage.2008.12.048. View

16.

Huppert T, Diamond S, Franceschini M, Boas D . HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain. Appl Opt. 2009; 48(10):D280-98. PMC: 2761652. DOI: 10.1364/ao.48.00d280. View

17.

Tottenham N, Tanaka J, Leon A, McCarry T, Nurse M, Hare T . The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Res. 2009; 168(3):242-9. PMC: 3474329. DOI: 10.1016/j.psychres.2008.05.006. View

18.

Saager R, Telleri N, Berger A . Two-detector Corrected Near Infrared Spectroscopy (C-NIRS) detects hemodynamic activation responses more robustly than single-detector NIRS. Neuroimage. 2011; 55(4):1679-85. DOI: 10.1016/j.neuroimage.2011.01.043. View

19.

Beauchamp M, Beurlot M, Fava E, Nath A, Parikh N, Saad Z . The developmental trajectory of brain-scalp distance from birth through childhood: implications for functional neuroimaging. PLoS One. 2011; 6(9):e24981. PMC: 3177859. DOI: 10.1371/journal.pone.0024981. View

20.

Gagnon L, Yucel M, Dehaes M, Cooper R, Perdue K, Selb J . Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. Neuroimage. 2011; 59(4):3933-40. PMC: 3279595. DOI: 10.1016/j.neuroimage.2011.10.054. View