Exogenous Testosterone, Aging, and Changes in Behavioral Response of Gonadally Intact Male Mice

Overview

Journal J Exp Neurosci

Publisher Sage Publications

Specialty Neurology

Date 2016 May 10

PMID 27158222

Citations 4

Authors

Olakunle J Onaolapo

Adejoke Y Onaolapo

Tope A Omololu

Adedunke T Oludimu

Toluwalase Segun-Busari

Taofeeq Omoleke

Affiliations

Soon will be listed here.

Abstract

This study tested the hypothesis that aging significantly affects the influence of exogenous testosterone on neurobehavior in gonadally intact male mice. Groups of prepubertal and aged male mice received daily vehicle or testosterone propionate (TP; 2.5 or 5.0 mg/kg intraperitoneal [i.p.]) for 21 days. Behaviors were assessed on days 1 and 21. Weight gain was significant in prepubertal mice. Locomotion and rearing increased in prepubertal mice after first dose and decreased after last dose of TP. Rearing was suppressed in aged mice throughout. Suppression of grooming occurred in both age groups at day 21. Significant increase in working memory in both age groups was seen in the radial-arm maze (at specific doses) and in prepubertal mice in the Y-maze. Elevated plus maze test showed mixed anxiolytic/anxiogenic effects. Aged mice had higher serum testosterone. In conclusion, age is an important determinant for the influence of exogenous testosterone on behavior in gonadally intact male mice.

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