Health-related Quality of Life and Affective Status in Liver Transplant Recipients and Patients on the Waiting List with Low MELD Scores

Overview

Journal HPB (Oxford)

Publisher Elsevier

Specialty Gastroenterology

Date 2016 May 8

PMID 27154809

Citations 11

Authors

Christian Benzing

Nicco Krezdorn

Julia Forster

Andreas Hinz

Felix Krenzien

Georgi Atanasov

Moritz Schmelzle

Hans-Michael Hau

Michael Bartels

Affiliations

Soon will be listed here.

Abstract

Background: This study seeks to examine the impact of orthotopic liver transplantation (OLT) on Health-Related Quality of Life (HRQoL) and mental health in patients with different MELD scores.

Methods: Patients who has undergone orthotopic liver transplant (OLT) or were on the waiting list for OLT were submitted to HRQoL and depression/anxiety assessment by questionnaire: Short-Form 36 (SF-36), Questions on Life Satisfaction (FLZ-M), Patient Health Questionnaire-4 (PHQ-4). Data were analysed following division of patients into three groups: pretransplant patients with a MELD score <10, ≥10, and OLT recipients.

Results: The surveys were sent to 940 consecutive patients within one week in June 2013. Of these 940 patients, 869 (92.4%) met the inclusion criteria. In total, 291 (33.5%) eligible questionnaires (OLT group: 235, MELD <10: 25; MELD _10: 31) were suitable for analysis. General health (GH), vitality (VIT), and mental health (MH) were lower in both pretransplant groups compared to the OLT group (all p < 0.05). Anxiety and depression were higher in the MELD <10 group than in the OLT group (anxiety: p < 0.05; depression: p < 0.01).

Discussion: Patients with low MELD scores seem to benefit from OLT with regards to HRQoL and mental health.

Citing Articles

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Quality of life associated with immunosuppressant treatment adherence in liver transplant recipients: A cross-sectional study.

Shafiekhani M, Shahabinezhad F, Tavakoli Z, Tarakmeh T, Haem E, Sari N Front Pharmacol. 2023; 14:1051350.

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Quality of Life Domains in Breast Cancer Survivors: The Relationship Between Importance and Satisfaction Ratings.

Hinz A, Zenger M, Schmalbach B, Brahler E, Hofmeister D, Petrowski K Front Psychol. 2022; 13:923537.

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The 3-T Model of Informed Consent for Nonstandard Risk Donors: A Proposal for Transplant Clinical Practice.

Grossi A, Nicoli F, De Feo T, Cardillo M, Biffa G, Pegoraro R Transplant Direct. 2021; 7(11):e782.

PMID: 34712782 PMC: 8547922. DOI: 10.1097/TXD.0000000000001238.

Analysis of Quality of Life, Depression, and Sexual Function in Patients on the Liver Transplant List.

Fidan C, Akdur A, Kirnap M, Selcuk H, Yildirim S, Moray G Turk J Gastroenterol. 2021; 32(9):801-807.

PMID: 34609310 PMC: 8975440. DOI: 10.5152/tjg.2021.21229.

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