Synthesis of Isoquinolines Via Rh-catalyzed C-H Activation/C-N Cyclization with Diazodiesters or Diazoketoesters As a C2 Source

Synthesis of isoquinolines based on efficient C-C and C-N bond formation through Rh(iii)-catalyzed C-H activation and subsequent intramolecular cyclization is reported. Diazodiesters serving as a C2 source in the newly formed heterocycles are first demonstrated. Additionally, the Rh(iii)-catalyzed direct C-H activation/cyclization of benzimidates with diazoketoesters is also described.